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Octbeta2R Octopamine beta2 receptor [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41549, updated on 4-Jan-2025

Summary

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Official Symbol
Octbeta2Rprovided by FlyBase
Official Full Name
Octopamine beta2 receptorprovided by FlyBase
Primary source
FLYBASE:FBgn0038063
Locus tag
Dmel_CG33976
See related
AllianceGenome:FB:FBgn0038063
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0170980.184; anon-WO0170980.185; CG18553; CG33976; CG6989; DmCG6989; Dmel\CG33976; DmOctbeta2R; Dm_3R:45121; octb2R; Octb2R; OctB2R; Octbeta-like; OctBeta2; octbeta2r; octbeta2R; Octbeta2r; OCTbeta2R
Summary
Enables octopamine receptor activity. Involved in several processes, including adenylate cyclase-activating G protein-coupled receptor signaling pathway; ovulation; and positive regulation of synaptic assembly at neuromuscular junction. Located in plasma membrane. Is expressed in several structures, including adult octopaminergic neurons; epithelial tube; fat body; gland; and somatic muscle cell. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); disease of metabolism (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Orthologous to human ADRB1 (adrenoceptor beta 1); ADRB2 (adrenoceptor beta 2); and ADRB3 (adrenoceptor beta 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Octbeta2R in Genome Data Viewer
Location:
87C1-87C2; 3-52 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12550625..12595725, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8376347..8421447, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Octopamine beta3 receptor Neighboring gene long non-coding RNA:CR46016 Neighboring gene Hugin Neighboring gene mir-284 stem loop Neighboring gene long non-coding RNA:CR46017 Neighboring gene long non-coding RNA:CR44942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of β-adrenergic-like octopamine receptors during Drosophila development. Ohhara Y, et al. Zoolog Sci, 2012 Feb. PMID 22303848
  2. Additive Expression of Consolidated Memory through Drosophila Mushroom Body Subsets. Yang CH, et al. PLoS Genet, 2016 May. PMID 27195782, Free PMC Article
  3. An octopamine-specific GRAB sensor reveals a monoamine relay circuitry that boosts aversive learning. Lv M, et al. Natl Sci Rev, 2024 May. PMID 38798960, Free PMC Article
  4. Genetic and Neurobiological Analyses of the Noradrenergic-like System in Vulnerability to Sugar Overconsumption Using a Drosophila Model. Branch A, et al. Sci Rep, 2017 Dec 15. PMID 29247240, Free PMC Article
  5. Neural mechanisms of reward in insects. Perry CJ, et al. Annu Rev Entomol, 2013. PMID 23020615

See all (110) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables G protein-coupled amine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables octopamine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables octopamine receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables octopamine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fertilization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
octopamine beta2 receptor
Names
CG33976-PA
CG33976-PC
CG33976-PD
CG33976-PE
CG33976-PF
CG33976-PG
OctBeta2R
Octbeta2R-PA
Octbeta2R-PC
Octbeta2R-PD
Octbeta2R-PE
Octbeta2R-PF
Octbeta2R-PG
octopamine beta receptor
octopamine receptor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12550625..12595725 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001316576.1 → NP_001303505.1  octopamine beta2 receptor, isoform G [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNM5, Q4LBB9, Q9VG53, Q9VG54
    UniProtKB/TrEMBL
    A0A126GUT9
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor

  2. NM_001260149.2 → NP_001247078.1  octopamine beta2 receptor, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247078.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNM5, Q4LBB9, Q9VG53, Q9VG54
    UniProtKB/TrEMBL
    A0A126GUT9
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor

  3. NM_001260148.1 → NP_001247077.1  octopamine beta2 receptor, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247077.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNM5, Q4LBB9, Q9VG53, Q9VG54
    UniProtKB/TrEMBL
    A0A126GUT9
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor

  4. NM_001260147.1 → NP_001247076.1  octopamine beta2 receptor, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247076.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNM5, Q4LBB9, Q9VG53, Q9VG54
    UniProtKB/TrEMBL
    A0A126GUT9
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor

  5. NM_001038960.3 → NP_001034049.1  octopamine beta2 receptor, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001034049.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7FNM5, Q4LBB9, Q9VG53, Q9VG54
    UniProtKB/TrEMBL
    A0A126GUT9
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor

  6. NM_001170125.3 → NP_001163596.2  octopamine beta2 receptor, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163596.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIJ4
    Conserved Domains (2) summary
    pfam00001
    Location:170 → 465
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:164 → 342
    7tm_4; Olfactory receptor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A126GUT9 A0A126GUT9
E1JIJ4 E1JIJ4
Q4LBB9.2 Q4LBB9

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