U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Vha55 Vacuolar H[+]-ATPase 55kD subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41550, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
Vha55provided by FlyBase
Official Full Name
Vacuolar H[+]-ATPase 55kD subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0005671
Locus tag
Dmel_CG17369
See related
AllianceGenome:FB:FBgn0005671
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1208/13; ATP6V1B1; CG17369; Dmel\CG17369; l(3)87Ca; l(3)j2E9; l(3)SzA; SzA; v-ATPase; V-ATPase; V-type H+-ATPase; VA; VAT-2; vha55
Summary
Contributes to proton-transporting ATPase activity, rotational mechanism. Involved in proton transmembrane transport and vacuolar acidification. Located in brush border; early endosome; and perinuclear region of cytoplasm. Part of plasma membrane proton-transporting V-type ATPase complex. Is expressed in several structures, including Malpighian tubule; adult CNS glial cell; anterior-posterior subdivision of organism; gland; and gut section. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Orthologous to several human genes including ATP6V1B2 (ATPase H+ transporting V1 subunit B2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Vha55 in Genome Data Viewer
Location:
87C2-87C3; 3-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12623762..12627829, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8449484..8453551, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46017 Neighboring gene long non-coding RNA:CR44942 Neighboring gene Sorting nexin 3 Neighboring gene CCR4-NOT transcription complex subunit 10

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletions of two heat-activated loci in Drosophila melanogaster and their effects on heat-induced protein synthesis. Ish-Horowicz D, et al. Cell, 1977 Nov. PMID 411575
  2. The SzA mutations of the B subunit of the Drosophila vacuolar H+ ATPase identify conserved residues essential for function in fly and yeast. Du J, et al. J Cell Sci, 2006 Jun 15. PMID 16735441
  3. Involvement of V-ATPase in the regulation of cell size in the fly's visual system. Pyza E, et al. J Insect Physiol, 2004 Nov. PMID 15607501
  4. Vacuolar ATPase is required for ERK-dependent wound healing in the Drosophila embryo. Fraire-Zamora JJ, et al. Wound Repair Regen, 2018 Jan. PMID 29418044
  5. The roles of V-type H(+)-ATPase and Na(+)/K(+)-ATPase in energizing K(+) and H(+) transport in larval Drosophila gut epithelia. D'Silva NM, et al. J Insect Physiol, 2017 Apr. PMID 28188726

See all (143) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATPase activity, rotational mechanism IC
Inferred by Curator
more info
 PubMed 
contributes_to proton-transporting ATPase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
 PubMed 
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
contributes_to proton-transporting ATPase activity, rotational mechanism IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IC
Inferred by Curator
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in vacuolar acidification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vacuolar acidification IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in brush border IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane HDA PubMed 
part_of plasma membrane proton-transporting V-type ATPase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of proton-transporting V-type ATPase, V1 domain IEA
Inferred from Electronic Annotation
more info
  
part_of vacuolar proton-transporting V-type ATPase, V1 domain ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
vacuolar H[+]-ATPase 55kD subunit
Names
B subunit
B subunit of V-ATPase
CG17369-PA
CG17369-PB
CG17369-PC
V-ATPase B-subunit
V-ATPase subunit B
V1 B subunit
Vha55-PA
Vha55-PB
Vha55-PC
vacuolar ATP synthase subunit B
vacuolar ATPase B subunit
vacuolar H+-ATPase 55kD B subunit
vacuolar H+ATPase subunit B
vacuolar H[+]-ATPase
vacuolar H[+]-ATPase 55-kDa B subunit
vacuolar H[+]-ATPase 55kD B subunit

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12623762..12627829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057560.4 → NP_476908.1  vacuolar H[+]-ATPase 55kD subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31409, Q53YH8, Q9VG52
    UniProtKB/TrEMBL
    E1JIJ5
    Related
    FBpp0082139
    Conserved Domains (1) summary
    TIGR01040
    Location:25 → 488
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  2. NM_169475.2 → NP_731726.1  vacuolar H[+]-ATPase 55kD subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31409, Q53YH8, Q9VG52
    UniProtKB/TrEMBL
    E1JIJ5
    Related
    FBpp0082140
    Conserved Domains (1) summary
    TIGR01040
    Location:25 → 488
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit

  3. NM_001170126.1 → NP_001163597.1  vacuolar H[+]-ATPase 55kD subunit, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163597.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P31409, Q53YH8, Q9VG52
    UniProtKB/TrEMBL
    E1JIJ5
    Conserved Domains (1) summary
    TIGR01040
    Location:25 → 488
    V-ATPase_V1_B; V-type (H+)-ATPase V1, B subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JIJ5 E1JIJ5
P31409.1 P31409

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous