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Arp1 Actin-related protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41566, updated on 9-Dec-2024

Summary

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Official Symbol
Arp1provided by FlyBase
Official Full Name
Actin-related protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0011745
Locus tag
Dmel_CG6174
See related
AllianceGenome:FB:FBgn0011745
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Actr87C; Arp; arp-1; Arp-1; arp1; ARP1; Arp87c; Arp87C; ARP87C; CG6174; Dmel\CG6174; gdl; grid
Summary
Involved in anterograde axonal transport; axonal transport of mitochondrion; and retrograde axonal transport. Predicted to be part of dynactin complex. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval midgut primordium; ganglia; and gut section. Orthologous to several human genes including ACTR1A (actin related protein 1A). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Arp1 in Genome Data Viewer
Location:
87C5-87C5; 3-52 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12691743..12694232)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8517465..8519954)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene karmoisin Neighboring gene Suppressor of fused Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genes encoding actin-related proteins of Drosophila melanogaster. Fyrberg C, et al. J Mol Biol, 1994 Aug 19. PMID 8064864
  2. Actin' like actin? Mullins RD, et al. Trends Cell Biol, 1996 Jun. PMID 15157457
  3. Dynactin is necessary for synapse stabilization. Eaton BA, et al. Neuron, 2002 May 30. PMID 12062020
  4. The actin-related proteins. Frankel S, et al. Curr Opin Cell Biol, 1996 Feb. PMID 8791406
  5. Symmetry breaking in the female germline cyst. Nashchekin D, et al. Science, 2021 Nov 12. PMID 34762476, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A missense mutation in the dynactin Arp1 subunit causes most oskar mRNA to localise in the posterior cytoplasm rather than cortically.
    Title: Localised dynactin protects growing microtubules to deliver oskar mRNA to the posterior cortex of the Drosophila oocyte.
  2. Results show that dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
    Title: Dynactin is required for coordinated bidirectional motility, but not for dynein membrane attachment.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anterograde axonal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axonal transport of mitochondrion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based movement IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in retrograde axonal transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Actin-related protein 1
Names
Actin-related protein 87C
Arp1-PA
CG6174-PA
actin related protein 1
gridlock

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12691743..12694232
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079607.3 → NP_524331.2  Actin-related protein 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524331.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P45889, Q9VG37
    Related
    FBpp0082121
    Conserved Domains (2) summary
    smart00268
    Location:9 → 376
    ACTIN; Actin
    cl17037
    Location:5 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P45889.2 P45889

Gene LinkOut

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