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PolQ DNA polymerase theta [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41571, updated on 9-Dec-2024

Summary

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Official Symbol
PolQprovided by FlyBase
Official Full Name
DNA polymerase thetaprovided by FlyBase
Primary source
FLYBASE:FBgn0002905
Locus tag
Dmel_CG6019
See related
AllianceGenome:FB:FBgn0002905
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0443/09; AAF54858; CG6019; Dmel\CG6019; DNApol-theta; mus-308; mus308; Mus308; Nuc3; Pol theta; polq; POLQ
Summary
Enables DNA-directed DNA polymerase activity. Involved in DNA metabolic process. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; central brain primordium; embryonic/larval midgut primordium; and mesoderm. Orthologous to human POLQ (DNA polymerase theta). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See PolQ in Genome Data Viewer
Location:
87C6-87C6; 3-52 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12705523..12712299, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8531245..8538021, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Actin-related protein 1 Neighboring gene uncharacterized protein Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene Malic enzyme Neighboring gene long non-coding RNA:CR44231

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mitochondrial nuclease is modified in Drosophila mutants (mus308) that are hypersensitive to DNA crosslinking agents. Sakaguchi K, et al. Mol Gen Genet, 1990 Dec. PMID 2125112
  2. DNA polymerase POLQ and cellular defense against DNA damage. Yousefzadeh MJ, et al. DNA Repair (Amst), 2013 Jan 1. PMID 23219161, Free PMC Article
  3. The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos. Pang M, et al. DNA Repair (Amst), 2005 Aug 15. PMID 15961355
  4. The hypermutability conferred by the mus308 mutation of Drosophila is not specific for cross-linking agents. Aguirrezabalaga I, et al. Mutat Res, 1995 May. PMID 7739612
  5. A possible functional role for a new class of eukaryotic DNA polymerases. Burtis KC, et al. Curr Biol, 1997 Dec 1. PMID 9382854

See all (89) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.
    Title: Persistent DNA damage signaling and DNA polymerase theta promote broken chromosome segregation.
  2. Both polymerase and ATPase activities are required during microhomology-mediated end joining and interstrand crosslink repair.
    Title: Drosophila DNA polymerase theta utilizes both helicase-like and polymerase domains during microhomology-mediated end joining and interstrand crosslink repair.
  3. DNA polymerase theta, encoded by the mus308 gene, plays a crucial role in DNA ligase 4-independent alternative end joining.
    Title: Dual roles for DNA polymerase theta in alternative end-joining repair of double-strand breaks in Drosophila.
  4. mus 308 gene product localizes throughout nuclei in wild-type cells but appears to be absent in a mus 308 mutant Drosophila
    Title: The Drosophila mus 308 gene product, implicated in tolerance of DNA interstrand crosslinks, is a nuclear protein found in both ovaries and embryos.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-deoxyribose-5-phosphate lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-directed DNA polymerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA synthesis involved in DNA repair IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA-templated DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via alternative nonhomologous end joining IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via alternative nonhomologous end joining IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleotide-excision repair involved in interstrand cross-link repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in replication fork processing IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
DNA polymerase theta
Names
CG6019-PA
Nuclease-3
PolQ-PA
mutagen-sensitive 308
pol theta
NP_524333.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12705523..12712299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079609.3 → NP_524333.1  DNA polymerase theta [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524333.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18475, Q5BI65
    Related
    FBpp0082131
    Conserved Domains (5) summary
    cd08638
    Location:1668 → 2053
    DNA_pol_A_theta; DNA polymerase theta is a low-fidelity family A enzyme implicated in translesion synthesis and in somatic hypermutation
    smart00490
    Location:542 → 616
    HELICc; helicase superfamily c-terminal domain
    COG0749
    Location:1489 → 2055
    PolA; DNA polymerase I - 3'-5' exonuclease and polymerase domains [Replication, recombination and repair]
    COG1204
    Location:209 → 978
    BRR2; Replicative superfamily II helicase [Replication, recombination and repair]
    pfam00270
    Location:251 → 404
    DEAD; DEAD/DEAH box helicase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O18475.1 O18475

Gene LinkOut

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