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Spc25 Spc25 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41585, updated on 4-Jan-2025

Summary

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Official Symbol
Spc25provided by FlyBase
Official Full Name
Spc25provided by FlyBase
Primary source
FLYBASE:FBgn0087021
Locus tag
Dmel_CG7242
See related
AllianceGenome:FB:FBgn0087021
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:LD37196; cal2; Cal2; CG7242; Dmel\CG7242; dmSpc25R; l(3)87Da; l(3)A34-1; l(3)A46-1; l(3)c00064; l(3)S3; Mitch; S3; spc25
Summary
Involved in meiotic metaphase chromosome alignment; meiotic spindle organization; and mitotic metaphase chromosome alignment. Located in kinetochore. Part of Ndc80 complex. Is expressed in organism. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Spc25 in Genome Data Viewer
Location:
87D5-87D5; 3-53 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12961745..12963249)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8787467..8788971)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene beaten path Vb Neighboring gene long non-coding RNA:CR44236 Neighboring gene granny smith Neighboring gene Cytochrome P450 304a1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel mutation in the N-terminal domain of Drosophila BubR1 affects the spindle assembly checkpoint function of BubR1. Duranteau M, et al. Biol Open, 2016 Nov 15. PMID 27742609, Free PMC Article
  2. Mutations in the Drosophila rough deal gene affecting RZZ kinetochore function. Menant A, et al. Biol Cell, 2020 Oct. PMID 32602944
  3. Transgenerational propagation and quantitative maintenance of paternal centromeres depends on Cid/Cenp-A presence in Drosophila sperm. Raychaudhuri N, et al. PLoS Biol, 2012. PMID 23300376, Free PMC Article
  4. RZZ and Mad1 dynamics in Drosophila mitosis. Défachelles L, et al. Chromosome Res, 2015 Jun. PMID 25772408, Free PMC Article
  5. A mitotic role for Mad1 beyond the spindle checkpoint. Emre D, et al. J Cell Sci, 2011 May 15. PMID 21511728

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic metaphase chromosome alignment IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Ndc80 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Spc25
Names
CG7242-PA
Spc25-PA
chromosome alignment defect 2
lethal (3) 87Da
lethal (3) c00064
mitch
mitotic chaos

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12961745..12963249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_141982.3 → NP_650239.1  Spc25 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650239.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3V7
    Related
    FBpp0082158
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3V7.1 Q9V3V7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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