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CtBP C-terminal Binding Protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41602, updated on 9-Dec-2024

Summary

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Official Symbol
CtBPprovided by FlyBase
Official Full Name
C-terminal Binding Proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0020496
Locus tag
Dmel_CG7583
See related
AllianceGenome:FB:FBgn0020496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0256/16; 256/16; BcDNA:GH07572; CG7583; ctbp; CTBP; dCtBP; Dm-CtBP; Dmel\CG7583; EP(3)3528; G9; l(3)03463; l(3)03464; l(3)87De; l(3)87DE; l(3)G9; RE01030; RE61183
Summary
Enables DNA-binding transcription factor binding activity; protein homodimerization activity; and transcription coregulator activity. Involved in several processes, including regulation of canonical Wnt signaling pathway; regulation of transcription by RNA polymerase II; and sensory organ precursor cell fate determination. Located in nucleus. Part of ISWI-type complex. Colocalizes with polytene chromosome. Is expressed in several structures, including adult head; antennal disc; epithelium; eye disc anterior to the morphogenetic furrow; and female germline cell. Orthologous to human CTBP1 (C-terminal binding protein 1) and CTBP2 (C-terminal binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See CtBP in Genome Data Viewer
Location:
87D8-87D9; 3-53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13011649..13026275)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8837371..8851997)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene lethal (3) 87Df

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association of class I histone deacetylases with transcriptional corepressor CtBP. Subramanian T, et al. FEBS Lett, 2003 Apr 10. PMID 12681518
  2. Role of NAD binding and catalytic residues in the C-terminal binding protein corepressor. Mani-Telang P, et al. FEBS Lett, 2007 Nov 13. PMID 17964573
  3. The Cynosure of CtBP: Evolution of a Bilaterian Transcriptional Corepressor. Raicu AM, et al. Mol Biol Evol, 2023 Feb 3. PMID 36625090, Free PMC Article
  4. C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein. Lee JS, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22138398
  5. CtBP represses Dpp signaling as a dimer. Bi C, et al. Biochem Biophys Res Commun, 2018 Jan 8. PMID 29225171

See all (269) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor.
    Title: A regulatory role for the unstructured C-terminal domain of the CtBP transcriptional corepressor.
  2. Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
    Title: Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
  3. Data show separable and cell-type-specific functions of Groucho (Gro) and C-terminal binding protein (CtBP) in a Notch signaling cascade involved lateral inhibition process.
    Title: Division of Labor: Roles of Groucho and CtBP in Notch-Mediated Lateral Inhibition that Controls Intestinal Stem Cell Differentiation in Drosophila.
  4. Thus, CtBP stabilizes cell fates following damage by opposing the destabilizing effects of the JNK/AP-1 and JAK/STAT pathways.
    Title: CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs.
  5. Here we provide evidence that although wild type CtBP negatively and dominantly influences Dpp signaling in fly presumptive wings, mutant CtBP unable to form dimer does not, indicating that dimerization is required for the repression role of CtBP in Dpp signaling in vivo.
    Title: CtBP represses Dpp signaling as a dimer.
  6. We found that TCF7L1 recruits the C-terminal binding protein (CtBP) and histone deacetylase 1 (HDAC1) to the DKK4 promoter to repress DKK4 gene expression. In the absence of TCF7L1, TCF7L2 and beta-catenin occupancy at the DKK4 promoter is stimulated and DKK4 expression is increased. These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
    Title: TCF7L1 recruits CtBP and HDAC1 to repress DICKKOPF4 gene expression in human colorectal cancer cells.
  7. Drosophila CtBP (dCtBP) was identified as a binding partner of Diap1; whether the interaction between Diap1 and dCtBP also occurs in human cells was tested.
    Title: C-terminal binding protein-mediated transcriptional repression is regulated by X-linked inhibitor of apoptosis protein.
  8. Data show that the differential recruitment of the co-repressors Gro and CtBP by H in a context-dependent manner ensures fine tuning of Notch signaling activity during eye development.
    Title: Fine tuning of Notch signaling by differential co-repressor recruitment during eye development of Drosophila.
  9. These results support a model where CtBP is a gene-specific regulator of Wingless signalling, with some targets requiring CtBP dimers for inhibition while other targets utilize CtBP monomers for activation of their expression.
    Title: The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.
  10. Results indicate that the structural and enzymatic features of C-terminal binding protein are critical for modulating this protein's activity in diverse developmental settings.
    Title: Conserved catalytic and C-terminal regulatory domains of the C-terminal binding protein corepressor fine-tune the transcriptional response in development.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription corepressor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory organ precursor cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of ISWI-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with polytene chromosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
C-terminal binding protein
Names
C-terminal-Binding-Protein
C-terminal-binding protein
CG7583-PA
CG7583-PB
CG7583-PC
CG7583-PD
CG7583-PE
CG7583-PF
CG7583-PG
CG7583-PH
CG7583-PI
CG7583-PJ
CtBP-PA
CtBP-PB
CtBP-PC
CtBP-PD
CtBP-PE
CtBP-PF
CtBP-PG
CtBP-PH
CtBP-PI
CtBP-PJ
drosophila C-terminal binding protein
lethal(3)87De
NP_001014617.1
NP_001262520.1
NP_001262521.1
NP_001262522.1
NP_001262523.1
NP_001262524.1
NP_524336.2
NP_731762.1
NP_731763.1
NP_731764.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13011649..13026275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014617.2 → NP_001014617.1  C-terminal binding protein, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014617.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O46036, O61283, Q59DX5, Q95SQ8, Q9VG02
    Conserved Domains (2) summary
    COG1052
    Location:45 → 354
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 345
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  2. NM_001275593.1 → NP_001262522.1  C-terminal binding protein, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262522.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGZ7
    Conserved Domains (2) summary
    COG1052
    Location:45 → 351
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 342
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  3. NM_001275595.1 → NP_001262524.1  C-terminal binding protein, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262524.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFT4
    Conserved Domains (2) summary
    COG1052
    Location:45 → 351
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 342
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  4. NM_001275594.1 → NP_001262523.1  C-terminal binding protein, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262523.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KFX5
    Conserved Domains (2) summary
    COG1052
    Location:45 → 351
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 342
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  5. NM_001275591.2 → NP_001262520.1  C-terminal binding protein, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262520.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGG9
    Conserved Domains (2) summary
    COG0111
    Location:26 → 352
    SerA; Phosphoglycerate dehydrogenase or related dehydrogenase [Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 342
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  6. NM_169491.2 → NP_731763.1  C-terminal binding protein, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731763.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2S3
    Related
    FBpp0082168
    Conserved Domains (2) summary
    COG1052
    Location:45 → 354
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 345
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  7. NM_079612.3 → NP_524336.2  C-terminal binding protein, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524336.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2S3
    Related
    FBpp0082167
    Conserved Domains (2) summary
    COG1052
    Location:45 → 354
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 345
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  8. NM_169490.2 → NP_731762.1  C-terminal binding protein, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731762.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2S3
    Related
    FBpp0082169
    Conserved Domains (2) summary
    COG1052
    Location:45 → 354
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 345
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  9. NM_001275592.1 → NP_001262521.1  C-terminal binding protein, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHB2
    Conserved Domains (2) summary
    COG1052
    Location:45 → 351
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 342
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor

  10. NM_169492.2 → NP_731764.1  C-terminal binding protein, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731764.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2S3
    Related
    FBpp0082170
    Conserved Domains (2) summary
    COG1052
    Location:45 → 354
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cd05299
    Location:28 → 345
    CtBP_dh; C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KFT4 A0A0B4KFT4
A0A0B4KFX5 A0A0B4KFX5
A0A0B4KGG9 A0A0B4KGG9
A0A0B4KGZ7 A0A0B4KGZ7
A0A0B4KHB2 A0A0B4KHB2
A4V2S3 A4V2S3
O46036.3 O46036

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