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Hsc70-2 Heat shock protein 70 cognate 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41609, updated on 9-Dec-2024

Summary

Official Symbol
Hsc70-2provided by FlyBase
Official Full Name
Heat shock protein 70 cognate 2provided by FlyBase
Primary source
FLYBASE:FBgn0001217
Locus tag
Dmel_CG7756
See related
AllianceGenome:FB:FBgn0001217
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7756; dhsc70; Dmel\CG7756; Hsc-2; HSC-70; hsc2; Hsc2; HSC2; hsc70; Hsc70; HSC70; HSC70-2; Hsc70.2; hsp70; HSP70cA8; HSP7B_DROME
Summary
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Predicted to be involved in chaperone cofactor-dependent protein refolding and protein refolding. Predicted to be active in cytoplasm and nucleus. Is expressed in adult head and adult heart. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Hsc70-2 in Genome Data Viewer
Location:
87D10-87D10; 3-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13044759..13047388)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8870481..8873110)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene snake Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
heat shock protein 70 cognate 2
Names
70 kDa heat shock protein, cytosolic A 8
CG7756-PA
Hs protein cognate 2
Hsc70-2-PA
Hsp cognate 2
heat shock protein cognate 2
heat shock protein cognate-2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13044759..13047388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079615.4NP_524339.1  heat shock protein 70 cognate 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524339.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P11146, Q5U0V1, Q9VFZ5
    Related
    FBpp0082175
    Conserved Domains (2) summary
    cd10233
    Location:6382
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:1632
    PTZ00009; heat shock 70 kDa protein; Provisional