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SRGAP3 SLIT-ROBO Rho GTPase activating protein 3 [ Gallus gallus (chicken) ]

Gene ID: 416115, updated on 17-Aug-2024

Summary

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Symbol
SRGAP3provided by CGNC
Full Name
SLIT-ROBO Rho GTPase activating protein 3provided by CGNC
Primary source
CGNC:50167
See related
Ensembl:ENSGALG00010019624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See SRGAP3 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
24
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19516714..19584828, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (19554841..19622991, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene oxytocin receptor Neighboring gene RAD18, E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC121106670 Neighboring gene uncharacterized LOC121106669 Neighboring gene THUMP domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SLIT-ROBO Rho GTPase-activating protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030604.3 → NP_001025775.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001025775.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    Q5ZLH5
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748 → 800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502 → 689
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

  2. NM_001389275.2 → NP_001376204.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    A0A1D5PJ10, A0A8V0ZA44
    Related
    ENSGALP00010028074.1, ENSGALT00010047379.1
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748 → 800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502 → 689
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  3. NM_001389276.2 → NP_001376205.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000252
    UniProtKB/TrEMBL
    A0A1L1RM91, A0A8V0ZA44
    Related
    ENSGALP00010028079.1, ENSGALT00010047388.1
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:724 → 776
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:481 → 665
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19516714..19584828 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015293125.4 → XP_015148611.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X1

    UniProtKB/TrEMBL
    F1NVK8
    Related
    ENSGALP00010028064.1, ENSGALT00010047362.1
    Conserved Domains (3) summary
    cd07684
    Location:26 → 278
    F-BAR_srGAP3; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 3
    cd11955
    Location:748 → 800
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:502 → 689
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...

  2. XM_040646288.2 → XP_040502222.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X2

    Conserved Domains (1) summary
    cl12013
    Location:26 → 278
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_025154499.3 → XP_025010267.1  SLIT-ROBO Rho GTPase-activating protein 3 isoform X3

    Conserved Domains (1) summary
    cl12013
    Location:26 → 278
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001468582.4 RNA Sequence

  2. XR_005839159.2 RNA Sequence

  3. XR_003077332.3 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19554841..19622991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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