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PLXND1 plexin D1 [ Gallus gallus (chicken) ]

Gene ID: 416124, updated on 17-Aug-2024

Summary

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Symbol
PLXND1provided by CGNC
Full Name
plexin D1provided by CGNC
Primary source
CGNC:6425
See related
Ensembl:ENSGALG00010019208
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See PLXND1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
36
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19705759..19772289, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (19744007..19810537, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054397 Neighboring gene rhodopsin Neighboring gene H1.8 linker histone Neighboring gene uncharacterized LOC107054398 Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene uncharacterized LOC121106672 Neighboring gene uncharacterized LOC107054396

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development. Kwiatkowski SC, et al. Dev Biol, 2016 Mar 1. PMID 26783882, Free PMC Article
  2. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PlexinD1 is involved in vascular response to antiangiogenic Sema3 signaling that guides the formation of the iris and limbal blood vessels by inhibiting VEGF signaling.
    Title: PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endothelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of semaphorin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
plexin-D1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    19705759..19772289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_414455.7 → XP_414455.4  plexin-D1

    UniProtKB/TrEMBL
    A0A3Q2U1R1, A0A8V0Z9M7
    Related
    ENSGALP00010027639.1, ENSGALT00010046425.1
    Conserved Domains (6) summary
    cd11247
    Location:42 → 543
    Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1
    cd01180
    Location:889 → 977
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:545 → 597
    PSI; Plexin repeat
    pfam08337
    Location:1347 → 1891
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:618 → 695
    TIG_plexin; TIG domain
    cl15674
    Location:979 → 1063
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    19744007..19810537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040682253.2 → XP_040538187.1  plexin-D1

    UniProtKB/TrEMBL
    A0A3Q2U1R1, A0A8V0Z9M7
    Conserved Domains (6) summary
    cd11247
    Location:42 → 543
    Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1
    cd01180
    Location:889 → 977
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    pfam01437
    Location:545 → 597
    PSI; Plexin repeat
    pfam08337
    Location:1347 → 1891
    Plexin_cytopl; Plexin cytoplasmic RasGAP domain
    pfam17960
    Location:618 → 695
    TIG_plexin; TIG domain
    cl15674
    Location:979 → 1063
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
Nucleotide Protein Strain
Heading Accession and Version

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