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CG8630 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41629, updated on 4-Jan-2025

Summary

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Official Symbol
CG8630provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038130
Locus tag
Dmel_CG8630
See related
AllianceGenome:FB:FBgn0038130
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel SAMN; Dmel\CG8630
Summary
Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult head; embryonic proventriculus; embryonic salivary gland duct; and embryonic/larval salivary gland common duct. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See CG8630 in Genome Data Viewer
Location:
87E3-87E4; 3-53 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13279721..13284527)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9105443..9110249)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Suppressor of variegation 3-7 Neighboring gene ravus Neighboring gene TBC1 domain family member 5 Neighboring gene uncharacterized protein Neighboring gene apnoia

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular genetics and evolution of pheromone biosynthesis in Lepidoptera. Roelofs WL, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876197, Free PMC Article
  2. Seasonal gene expression kinetics between diapause phases in Drosophila virilis group species and overwintering differences between diapausing and non-diapausing females. Salminen TS, et al. Sci Rep, 2015 Jun 11. PMID 26063442, Free PMC Article
  3. Molecular evolution and functional diversification of fatty acid desaturases after recurrent gene duplication in Drosophila. Fang S, et al. Mol Biol Evol, 2009 Jul. PMID 19307313, Free PMC Article
  4. Evolution of the integral membrane desaturase gene family in moths and flies. Knipple DC, et al. Genetics, 2002 Dec. PMID 12524345, Free PMC Article
  5. Changes in neuronal CycD/Cdk4 activity affect aging, neurodegeneration, and oxidative stress. Icreverzi A, et al. Aging Cell, 2015 Oct. PMID 26219626, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
  
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables stearoyl-CoA 9-desaturase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG8630-PA
NP_731781.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13279721..13284527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169500.2 → NP_731781.1  uncharacterized protein Dmel_CG8630 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731781.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFX5
    Related
    FBpp0082205
    Conserved Domains (2) summary
    cd03505
    Location:90 → 330
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
    pfam00487
    Location:91 → 297
    FA_desaturase; Fatty acid desaturase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFX5 Q9VFX5

Gene LinkOut

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