wntD wnt inhibitor of Dorsal [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wntDprovided by FlyBase
Official Full Name: wnt inhibitor of Dorsalprovided by FlyBase
Primary source: FLYBASE:FBgn0038134
Locus tag: Dmel_CG8458
See related: AllianceGenome:FB:FBgn0038134
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8458; Dm DWnt8; Dmel\CG8458; Dwnt-8; DWnt-8; Dwnt-D; Dwnt8; DWnt8; DWntD; wnt8; Wnt8; Wntd; WntD
Summary: Enables frizzled binding activity. Involved in several processes, including defense response to Gram-positive bacterium; germ cell migration; and ventral furrow formation. Located in extracellular region. Is expressed in several structures, including antennal anlage; antennal primordium; central brain anlage; central brain primordium; and head epidermis primordium. Human ortholog(s) of this gene implicated in Hirschsprung's disease. Orthologous to human WNT8A (Wnt family member 8A) and WNT8B (Wnt family member 8B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13292052..13293198, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9117774..9118920, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	NAS Non-traceable Author Statement more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to Gram-positive bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in germ cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ventral furrow formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info