Dic1 Dicarboxylate carrier 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Dic1provided by FlyBase
Official Full Name: Dicarboxylate carrier 1provided by FlyBase
Primary source: FLYBASE:FBgn0027610
Locus tag: Dmel_CG8790
See related: AllianceGenome:FB:FBgn0027610
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH02431; CG8790; DmDic1p; Dmel\CG8790
Summary: Enables C4-dicarboxylate transmembrane transporter activity and inorganic anion transmembrane transporter activity. Involved in C4-dicarboxylate transport; inorganic anion transmembrane transport; and thiosulfate transport. Located in mitochondrion. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 19. Orthologous to human SLC25A10 (solute carrier family 25 member 10). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13364938..13369278)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9190660..9195000)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables oxaloacetate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxaloacetate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables thiosulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiosulfate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in gluconeogenesis	NAS Non-traceable Author Statement more info	PubMed
involved_in malate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in oxaloacetate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxaloacetate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphate ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphate ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sulfate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in thiosulfate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thiosulfate transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial inner membrane	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain