CCHa2 CCHamide-2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CCHa2provided by FlyBase
Official Full Name: CCHamide-2provided by FlyBase
Primary source: FLYBASE:FBgn0038147
Locus tag: Dmel_CG14375
See related: AllianceGenome:FB:FBgn0038147
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:RE10132; CCH2; CCH2a; ccha2; Ccha2; CCha2; CCHamid2; CCM; CG14375; Dm-CCHa2; Dmel\CG14375
Summary: Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway. Located in extracellular space. Is expressed in several structures, including CCHamide-2 neuron; embryonic/larval fat body; embryonic/larval gut; enteroendocrine cell; and gut section. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 87E8-87E8; 3-53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13389059..13395197, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9214781..9220919, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of unstable beta-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
Title: Effects of unstable β-PheRS on food avoidance, growth, and development are suppressed by the appetite hormone CCHa2.
Data indicate that the activation of CCHa2/CCHa2-R signaling promotes the sensation of good nutritional status in the larval brain, leading to Dilp-dependent tissue growth.
Title: Coupling of growth to nutritional status: The role of novel periphery-to-brain signaling by the CCHa2 peptide in Drosophila melanogaster.
conclude that CCHamide-2 is an orexigenic peptide and an important factor for controlling developmental timing in Drosophila
Title: CCHamide-2 Is an Orexigenic Brain-Gut Peptide in Drosophila.
genetic disruption of either CCHa2 or CCHa2-R caused almost identical defects in larval growth and developmental timing
Title: The Nutrient-Responsive Hormone CCHamide-2 Controls Growth by Regulating Insulin-like Peptides in the Brain of Drosophila melanogaster.
orcokinin B, CCHamide 1, and CCHamide 2 expression in Drosophila is reported.
Title: More Drosophila enteroendocrine peptides: Orcokinin B and the CCHamides 1 and 2.
Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain.
Title: Expression patterns of the Drosophila neuropeptide CCHamide-2 and its receptor may suggest hormonal signaling from the gut to the brain.
G-protein-coupled receptors coded for by genes CG14593 and CG30106 that are selectively activated by Drosophila CCH-amide-1 and CCH-amide-2, respectively, were cloned.
Title: The Drosophila genes CG14593 and CG30106 code for G-protein-coupled receptors specifically activated by the neuropeptides CCHamide-1 and CCHamide-2.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISM Inferred from Sequence Model more info	PubMed