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Lkb1 Lkb1 kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41673, updated on 9-Dec-2024

Summary

Official Symbol
Lkb1provided by FlyBase
Official Full Name
Lkb1 kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038167
Locus tag
Dmel_CG9374
See related
AllianceGenome:FB:FBgn0038167
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Posey135; CG9374; dlkb1; dLKB1; Dmel\CG9374; DmLKB1; lkb1; LKB1; LKB1/PEUTZ JEGHERS KINASE; par-4; PAR-4; Par4; PAR4; STK11
Summary
Enables protein serine/threonine kinase activator activity and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; germ cell development; and regulation of intracellular signal transduction. Located in cell cortex; endosome; and nucleus. Is active in cytoplasmic side of plasma membrane. Is expressed in organism. Human ortholog(s) of this gene implicated in Peutz-Jeghers syndrome; familial melanoma; female reproductive organ cancer (multiple); and pancreatic cancer. Orthologous to human STK11 (serine/threonine kinase 11). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See Lkb1 in Genome Data Viewer
Location:
87F7-87F9; 3-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13676549..13679430)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9502271..9505152)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene B52 Neighboring gene TWIK-related acid-sensitive K[+] channel 6 Neighboring gene uncharacterized protein Neighboring gene oocyte maintenance defects Neighboring gene falafel Neighboring gene uncharacterized protein Neighboring gene flyers-cup

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in border follicle cell delamination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dorsal closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in maintenance of neuroblast polarity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of TORC1 signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to cell cortex IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization to cell cortex IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell growth IEA
Inferred from Electronic Annotation
more info
 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
Lkb1 kinase
Names
CG9374-PA
CG9374-PB
CG9374-PC
CG9374-PD
CG9374-PE
CG9374-PF
CG9374-PH
CG9374-PI
CG9374-PJ
Lkb1-PA
Lkb1-PB
Lkb1-PC
Lkb1-PD
Lkb1-PE
Lkb1-PF
Lkb1-PH
Lkb1-PI
Lkb1-PJ
liver kinase B1
lkb1
NP_001163606.1
NP_650302.1
NP_731840.1
NP_731841.1
NP_731842.1
NP_731843.1
NP_731844.1
NP_731845.1
NP_731846.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    13676549..13679430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169544.2NP_731843.1  Lkb1 kinase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731843.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082280
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  2. NM_001170135.2NP_001163606.1  Lkb1 kinase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  3. NM_169541.3NP_731840.1  Lkb1 kinase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082276
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  4. NM_169547.3NP_731846.1  Lkb1 kinase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082283
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  5. NM_169543.3NP_731842.1  Lkb1 kinase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082279
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  6. NM_169545.3NP_731844.1  Lkb1 kinase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082281
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  7. NM_142045.4NP_650302.1  Lkb1 kinase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650302.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082277
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  8. NM_169546.3NP_731845.1  Lkb1 kinase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731845.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082282
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1
  9. NM_169542.3NP_731841.1  Lkb1 kinase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T9L5, Q9VFS7
    Related
    FBpp0082278
    Conserved Domains (2) summary
    smart00220
    Location:172435
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14119
    Location:178435
    STKc_LKB1; Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1