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HIC2 hypermethylated in cancer 2 [ Gallus gallus (chicken) ]

Gene ID: 416768, updated on 17-Aug-2024

Summary

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Official Symbol
HIC2provided by CGNC
Official Full Name
hypermethylated in cancer 2provided by CGNC
Primary source
CGNC:961
See related
Ensembl:ENSGALG00010024282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See HIC2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
7
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (254574..329976, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (260094..335533, complement)

Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 29 Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene serpin family D member 1 Neighboring gene uncharacterized LOC107051622 Neighboring gene ubiquitin conjugating enzyme E2 L3 Neighboring gene YdjC homolog (bacterial)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ESTs from brain and testis of White Leghorn and red junglefowl: annotation, bioinformatic classification of unknown transcripts and analysis of expression levels. Savolainen P, et al. Cytogenet Genome Res, 2005. PMID 16093725
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypermethylated in cancer 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277483.1 → NP_001264412.1  hypermethylated in cancer 2 protein

    See identical proteins and their annotated locations for NP_001264412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BX929888
    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036166.1, ENSGALT00010059246.1
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001277484.1 → NP_001264413.1  hypermethylated in cancer 2 protein

    See identical proteins and their annotated locations for NP_001264413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CN218984, JAENSK010000260
    UniProtKB/TrEMBL
    A0A1D5P7L2
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    254574..329976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046901117.1 → XP_046757073.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  2. XM_015275229.4 → XP_015130715.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  3. XM_015275232.4 → XP_015130718.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036144.1, ENSGALT00010059219.1
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  4. XM_015275230.4 → XP_015130716.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036170.1, ENSGALT00010059251.1
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  5. XM_025155429.3 → XP_025011197.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  6. XM_046901112.1 → XP_046757068.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  7. XM_046901114.1 → XP_046757070.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  8. XM_025155430.3 → XP_025011198.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036172.1, ENSGALT00010059253.1
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  9. XM_046901113.1 → XP_046757069.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036161.1, ENSGALT00010059241.1

  10. XM_046901115.1 → XP_046757071.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  11. XM_046901116.1 → XP_046757072.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036142.1, ENSGALT00010059216.1

  12. XM_046901110.1 → XP_046757066.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036168.1, ENSGALT00010059250.1

  13. XM_040647985.2 → XP_040503919.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
    Related
    ENSGALP00010036150.1, ENSGALT00010059226.1
    Conserved Domains (5) summary
    COG5189
    Location:207 → 480
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:490 → 510
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18334
    Location:3 → 122
    BTB_POZ_ZBTB30_HIC2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2)
    pfam00096
    Location:488 → 510
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:530 → 555
    zf-H2C2_2; Zinc-finger double domain

  14. XM_046901111.1 → XP_046757067.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    260094..335533 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046928090.1 → XP_046784046.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  2. XM_046928076.1 → XP_046784032.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  3. XM_046928079.1 → XP_046784035.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  4. XM_046928077.1 → XP_046784033.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  5. XM_046928078.1 → XP_046784034.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  6. XM_046928085.1 → XP_046784041.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  7. XM_046928087.1 → XP_046784043.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  8. XM_046928080.1 → XP_046784036.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  9. XM_046928086.1 → XP_046784042.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  10. XM_046928088.1 → XP_046784044.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  11. XM_046928089.1 → XP_046784045.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  12. XM_046928082.1 → XP_046784038.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  13. XM_046928083.1 → XP_046784039.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2

  14. XM_046928084.1 → XP_046784040.1  hypermethylated in cancer 2 protein isoform X1

    UniProtKB/TrEMBL
    A0A1D5P7L2
Nucleotide Protein Strain
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