Cht5 Chitinase 5 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cht5provided by FlyBase
Official Full Name: Chitinase 5provided by FlyBase
Primary source: FLYBASE:FBgn0038180
Locus tag: Dmel_CG9307
See related: AllianceGenome:FB:FBgn0038180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9307; Cht; cht5; DmCht5; DmCHT5; Dmel\CG9307
Summary: Enables chitin binding activity and chitinase activity. Involved in several processes, including chitin catabolic process; ecdysis, chitin-based cuticle; and regulation of tube size, open tracheal system. Located in extracellular space. Is expressed in tracheal primordium. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (13767549..13770732)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (9593271..9596454)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables chitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chitin binding	IDA Inferred from Direct Assay more info	PubMed
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables chitinase activity	IDA Inferred from Direct Assay more info	PubMed
enables chitinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chitin catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in chitin catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ecdysis, chitin-based cuticle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

NP_650314.1

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The following sections contain reference sequences that belong to a specific genome build. Explain