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ART1 ADP-ribosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 417, updated on 27-Nov-2024

Summary

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Official Symbol
ART1provided by HGNC
Official Full Name
ADP-ribosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:723
See related
Ensembl:ENSG00000129744 MIM:601625; AllianceGenome:HGNC:723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RT6; ART2; ARTC1; CD296
Summary
ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. The amino acid sequence consists of predominantly hydrophobic N- and C-terminal regions, which is characteristic of glycosylphosphatidylinositol (GPI)-anchored proteins. This gene was previously designated ART2. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See ART1 in Genome Data Viewer
Location:
11p15.4
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (3645128..3664416)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (3690584..3729789)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (3666358..3685646)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:3662929-3663642 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3081 Neighboring gene transient receptor potential cation channel subfamily C member 2 (pseudogene) Neighboring gene ADP-ribosyltransferase 5 Neighboring gene cholinergic receptor nicotinic alpha 10 subunit Neighboring gene nucleoporin 98 and 96 precursor Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. Okazaki IJ, et al. Biochemistry, 1994 Nov 1. PMID 7947688
  2. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer. Wennerberg E, et al. Sci Transl Med, 2022 Mar 16. PMID 35294260, Free PMC Article
  3. Chemotaxin-dependent translocation of immunoreactive ADP-ribosyltransferase-1 to the surface of human neutrophil polymorphs. Kefalas P, et al. Eur J Biochem, 1999 Feb. PMID 10092875
  4. Expression of ADP-ribosyltransferase 1 Is Associated with Poor Prognosis of Glioma Patients. Li Z, et al. Tohoku J Exp Med, 2016 Aug. PMID 27466078
  5. Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma. Song GL, et al. Int J Oncol, 2016 Aug. PMID 27277835

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
    Title: ART1 knockdown decreases the IL-6-induced proliferation of colorectal cancer cells.
  2. ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
    Title: ARTC1-mediated VAPB ADP-ribosylation regulates calcium homeostasis.
  3. Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.
    Title: Expression of the mono-ADP-ribosyltransferase ART1 by tumor cells mediates immune resistance in non-small cell lung cancer.
  4. Our data suggest that ART1 could regulate EMT by regulating the RhoA/ROCK1/AKT/beta-catenin pathway and its downstream factors (snail1, vimentin, N-cadherin and E-cadherin) and that it therefore plays an important role in the progression of colon carcinoma.
    Title: Regulation of the RhoA/ROCK/AKT/β-catenin pathway by arginine-specific ADP-ribosytransferases 1 promotes migration and epithelial-mesenchymal transition in colon carcinoma.
  5. up-regulation of ART1 expression is associated with the aggressiveness of glioma.
    Title: Expression of ADP-ribosyltransferase 1 Is Associated with Poor Prognosis of Glioma Patients.
  6. Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway
    Title: Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
  7. The altered function and expression of P2X7 and ART1 in the human CD39+ Treg or CD39- Treg cells could participate in the resistance against cell death induced by ATP or NAD.
    Title: Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets.
  8. This study provides evidence that ARTC1 is activated during the endoplasmic-reticulum stress response, which results in acute ADP-ribosylation of GRP78/BiP paralleling translational inhibition.
    Title: ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.
  9. ADPRT Ala762Val polymorphism may play a role in the etiology of squamous cell carcinoma of the head and neck or in linkage disequilibrium with other untyped protective alleles.
    Title: Genetic polymorphisms in DNA base-excision repair genes ADPRT, XRCC1, and APE1 and the risk of squamous cell carcinoma of the head and neck.
  10. ADP-ribosylation of HNP-1 appears to be primarily an activity of ART1 and occurs in inflammatory conditions and disease
    Title: ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC133217

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in sarcoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1
Names
ADP-ribosyltransferase 2
ADP-ribosyltransferase C2 and C3 toxin-like 1
mono(ADP-ribosyl)transferase 1
NP_004305.2
XP_011518416.1
XP_016873252.1
XP_054224799.1
XP_054224800.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004314.3 → NP_004305.2  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 precursor

    See identical proteins and their annotated locations for NP_004305.2

    Status: REVIEWED

    Source sequence(s)
    AC060812, BC069102, S74683
    Consensus CDS
    CCDS7744.1
    UniProtKB/Swiss-Prot
    P52961, Q6NTD2, Q96KT9
    Related
    ENSP00000250693.1, ENST00000250693.2
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 274
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    3645128..3664416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017763.3 → XP_016873252.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P52961, Q6NTD2, Q96KT9
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 274
    ART; NAD:arginine ADP-ribosyltransferase

  2. XM_011520114.4 → XP_011518416.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

    See identical proteins and their annotated locations for XP_011518416.1

    UniProtKB/Swiss-Prot
    P52961, Q6NTD2, Q96KT9
    Conserved Domains (1) summary
    pfam01129
    Location:39 → 274
    ART; NAD:arginine ADP-ribosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    3690584..3729789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368825.1 → XP_054224800.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

  2. XM_054368824.1 → XP_054224799.1  GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52961.2 GenPept UniProtKB/Swiss-Prot:P52961

Gene LinkOut

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