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foxo forkhead box, sub-group O [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41709, updated on 9-Dec-2024

Summary

Official Symbol
foxoprovided by FlyBase
Official Full Name
forkhead box, sub-group Oprovided by FlyBase
Primary source
FLYBASE:FBgn0038197
Locus tag
Dmel_CG3143
See related
AllianceGenome:FB:FBgn0038197
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
3143; Afx; Akh; anon-WO0118547.374; cg3143; CG3143; dfoxo; dfoxO; dFoxo; dFoxO; dFOXO; Dfoxo; DfoxO; DFOXO; Dmel\CG3143; DmQ95V5; fd88A; FKHR; foxO; fOXO; Foxo; FoxO; FOXO; Foxo1; FOXO1; Q95V55; TORC
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including regulation of autophagy; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of with a negative effect on regulation of hemocyte proliferation and regulation of organ growth. Located in cytosol and nucleus. Is expressed in several structures, including embryonic segment; embryonic/larval midgut primordium; epidermis; fat body; and gut section. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in alveolar rhabdomyosarcoma. Orthologous to several human genes including FOXO4 (forkhead box O4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

See foxo in Genome Data Viewer
Location:
88A5-88A8; 3-54 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14056945..14087978)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9882667..9913700)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Serine-GCT 2-2 Neighboring gene Niemann-Pick type C-2b Neighboring gene CCHamide-1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in cellular response to amino acid starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to starvation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in locomotor rhythm IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lipid storage IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of entry into reproductive diapause IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of feeding behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of octopamine signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of triglyceride catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_negative_effect regulation of hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
forkhead box, sub-group O
Names
CG3143-PB
CG3143-PC
CG3143-PF
CG3143-PG
CG3143-PH
dFOXO
forkhead Box O
forkhead bOX-containing protein, subfamily O
forkhead box
forkhead box sub-group O
forkhead box type O
forkhead box, subgroup O
forkhead box-containing protein, O subfamily
forkhead boxO transcription factor
forkhead transcription factor
foxo
foxo-PB
foxo-PC
foxo-PF
foxo-PG
foxo-PH
NP_001303426.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14056945..14087978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206483.3NP_996205.1  forkhead box, sub-group O, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996205.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KF42, Q95TK1, Q95V55, Q9VFN8
    Conserved Domains (1) summary
    cd00059
    Location:95175
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  2. NM_142073.5NP_650330.3  forkhead box, sub-group O, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650330.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGN1
    Conserved Domains (1) summary
    cd00059
    Location:95175
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  3. NM_001316497.1NP_001303426.1  forkhead box, sub-group O, isoform H [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A126GUT4
    Conserved Domains (1) summary
    cd00059
    Location:95175
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  4. NM_206482.3NP_996204.1  forkhead box, sub-group O, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996204.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7KF42, Q95TK1, Q95V55, Q9VFN8
    Conserved Domains (1) summary
    cd00059
    Location:95175
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
  5. NM_001275628.1NP_001262557.1  forkhead box, sub-group O, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262557.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGN1
    Conserved Domains (1) summary
    cd00059
    Location:95175
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...