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Recs1 Recs1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41724, updated on 9-Dec-2024

Summary

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Official Symbol
Recs1provided by FlyBase
Official Full Name
Recs1provided by FlyBase
Primary source
FLYBASE:FBgn0038209
Locus tag
Dmel_CG9722
See related
AllianceGenome:FB:FBgn0038209
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9722; Dmel\CG9722; dRECS1
Summary
Enables pH-gated calcium channel activity and pH-gated sodium channel activity. Involved in calcium ion transmembrane transport; positive regulation of intrinsic apoptotic signaling pathway; and sodium ion transmembrane transport. Located in Golgi apparatus. Is active in lysosomal membrane. Is expressed in adult head. Orthologous to human GRINA (glutamate ionotropic receptor NMDA type subunit associated protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Recs1 in Genome Data Viewer
Location:
88A10-88A10; 3-54 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14152885..14153829, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9978607..9979551, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Pihán P, et al. Sci Adv, 2021 Nov 12. PMID 34767445, Free PMC Article
  2. Knockdown of the putative Lifeguard homologue CG3814 in neurons of Drosophila melanogaster. M'Angale PG, et al. Genet Mol Res, 2016 Dec 19. PMID 28002605
  3. The Evolutionary Conserved Transmembrane BAX Inhibitor Motif (TMBIM) Containing Protein Family Members 5 and 6 Are Essential for the Development and Survival of Drosophila melanogaster. Zhang L, et al. Front Cell Dev Biol, 2021. PMID 34540824, Free PMC Article
  4. Age-dependent chromosomal distribution of male-biased genes in Drosophila. Zhang YE, et al. Genome Res, 2010 Nov. PMID 20798392, Free PMC Article
  5. A cautionary note for retrocopy identification: DNA-based duplication of intron-containing genes significantly contributes to the origination of single exon genes. Zhang YE, et al. Bioinformatics, 2011 Jul 1. PMID 21551137, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables pH-gated calcium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pH-gated sodium channel activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sodium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in organelle membrane ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
Recs1
Names
CG9722-PA
Recs1-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14152885..14153829 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142084.2 → NP_650341.1  Recs1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650341.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFM3
    Related
    FBpp0082367
    Conserved Domains (1) summary
    cd10428
    Location:44 → 261
    LFG_like; Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VFM3 Q9VFM3

Gene LinkOut

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