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su(Hw) suppressor of Hairy wing [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41740, updated on 4-Jan-2025

Summary

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Official Symbol
su(Hw)provided by FlyBase
Official Full Name
suppressor of Hairy wingprovided by FlyBase
Primary source
FLYBASE:FBgn0003567
Locus tag
Dmel_CG8573
See related
AllianceGenome:FB:FBgn0003567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8573; Dmel\CG8573; su(hw); su(HW); Su(hw); Su(Hw); Su(HW); SU(HW); suHw; SUHW; Su[Hw]
Summary
Enables chromatin insulator sequence binding activity; euchromatin binding activity; and sequence-specific DNA binding activity. Involved in negative regulation of macromolecule biosynthetic process; protein localization to euchromatin; and response to ecdysone. Located in chromatin and nucleus. Is expressed in several structures, including germline cell; gut section; head epidermis primordium; somatic trunk mesoderm derivative; and trunk visceral muscle primordium. Orthologous to human ZNF358 (zinc finger protein 358). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See su(Hw) in Genome Data Viewer
Location:
88B3-88B3; 3-55 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14304455..14308589, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10130177..10134311, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45596 Neighboring gene red Malpighian tubules Neighboring gene Intraflagellar transport 54 Neighboring gene RNA polymerase II subunit I Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The gypsy insulator of Drosophila melanogaster, together with its binding protein suppressor of Hairy-wing, facilitate high and precise expression of transgenes in Arabidopsis thaliana. She W, et al. Genetics, 2010 Aug. PMID 20516496, Free PMC Article
  2. Oogenesis in the suppressor of hairy-wing mutant of Drosophila melanogaster. II. Nucleolar morphology and in vitro studies of RNA protein synthesis. Klug WS, et al. J Exp Zool, 1970 Jun. PMID 5463647
  3. Study of long-distance functional interactions between Su(Hw) insulators that can regulate enhancer-promoter communication in Drosophila melanogaster. Savitskaya E, et al. Mol Cell Biol, 2006 Feb. PMID 16428433, Free PMC Article
  4. The Drosophila melanogaster suppressor of Hairy-wing protein binds to specific sequences of the gypsy retrotransposon. Spana C, et al. Genes Dev, 1988 Nov. PMID 2850261
  5. The acid domain located at the C-terminus of the Su(Hw) protein represses transcription in the yeast two-hybrid system. Mazur AM, et al. Dokl Biochem Biophys, 2005 Jan-Feb. PMID 15846971

See all (437) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Impact of Interactions between Su(Hw)-Dependent Insulators on the Transvection Effect in Drosophila melanogaster.
    Title: Impact of Interactions between Su(Hw)-Dependent Insulators on the Transvection Effect in Drosophila melanogaster.
  2. A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
    Title: A Drosophila insulator interacting protein suppresses enhancer-blocking function and modulates replication timing.
  3. M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
    Title: M1BP cooperates with CP190 to activate transcription at TAD borders and promote chromatin insulator activity.
  4. HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
    Title: HIPP1 stabilizes the interaction between CP190 and Su(Hw) in the Drosophila insulator complex.
  5. while the Su(Hw) protein remains stably associated with the promoters of these genes at different transcriptional state, the GAF protein level is significantly higher when transcription is activated.
    Title: Activation of Su(Hw)-Controlled Genes Is Associated with Increase in GAF Binding.
  6. Study highlights that Su(Hw) has a major developmental function as a transcriptional repressor, with the effect of its loss dependent upon the cell-specific factors.
    Title: Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells of Drosophila.
  7. the role of the Su(Hw) protein in Drosophila oogenesis as a transcription repressor
    Title: Insulator Protein Su(Hw) Is Indispensable for Amplification of Part of Drosophila Amplicons in Follicular Cells (DAFCs) during Early Oogenesis.
  8. Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila
    Title: Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila.
  9. Su(Hw) genomic sites separate into sequence subclasses comprised of combinations of modules, with subclasses enriched for different chromatin features.
    Title: Deciphering the DNA code for the function of the Drosophila polydactyl zinc finger protein Suppressor of Hairy-wing.
  10. Study of the role of Mod(mdg4)-67.2 and Su(Hw) proteins in the interaction between Su(Hw)-dependent insulator complexes and identifying the specific domains of the Su(Hw) protein required for insulation or mutual neutralization of insulators; demonstrated that the Su(Hw) protein zinc finger domain is involved in forming a functional insulator complex and cannot be replaced with the DNA-binding domain of the GAL4 protein
    Title: Zinc finger domain of Su(Hw) protein is required for the formation of functional Su(Hw)-dependent insulator complex.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin insulator sequence binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables euchromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin boundary formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to euchromatin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to ecdysone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
suppressor of hairy wing
Names
CG8573-PA
CG8573-PB
CG8573-PC
su(Hw)-PA
su(Hw)-PB
su(Hw)-PC
suppressor of Hair-Wing
suppressor of hairy-wing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14304455..14308589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079625.3 → NP_524349.1  suppressor of hairy wing, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524349.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08970, Q0KI74, Q9VFK9
    UniProtKB/TrEMBL
    A0A0B4K6W1
    Related
    FBpp0082405
    Conserved Domains (5) summary
    COG5048
    Location:312 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:598 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 368
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  2. NM_169574.2 → NP_731897.1  suppressor of hairy wing, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731897.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08970, Q0KI74, Q9VFK9
    UniProtKB/TrEMBL
    A0A0B4K6W1
    Related
    FBpp0082404
    Conserved Domains (5) summary
    COG5048
    Location:312 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:598 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 368
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001260169.2 → NP_001247098.1  suppressor of hairy wing, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247098.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08970, Q0KI74, Q9VFK9
    UniProtKB/TrEMBL
    A0A0B4K6W1
    Conserved Domains (5) summary
    COG5048
    Location:312 → 517
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:443 → 463
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:598 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348 → 368
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:484 → 508
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K6W1 A0A0B4K6W1
P08970.2 P08970

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