Set8 SET domain containing 8 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Set8provided by FlyBase
Official Full Name: SET domain containing 8provided by FlyBase
Primary source: FLYBASE:FBgn0011474
Locus tag: Dmel_CG3307
See related: AllianceGenome:FB:FBgn0011474
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3307; Dmel\CG3307; dPR-Set7; dSet8; dSET8; l(3)neo41; Pr-set-7; pr-set7; pr-Set7; Pr-set7; PR-Set7; PR-SET7; PR/SET07; PrSet7; PRSet7; PRSET7; Set7; SET8
Summary: Enables histone H4K20 monomethyltransferase activity. Involved in DNA damage checkpoint signaling; chromosome condensation; and heterochromatin formation. Located in polytene chromosome. Is expressed in several structures, including CNS glial cell; antennal primordium; anterior endoderm; anterior endoderm anlage; and head epidermis primordium. Orthologous to human KMT5A (lysine methyltransferase 5A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: 88B3-88B3; 3-55 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14316038..14320494)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10141760..10146216)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation.
Title: Drosophila melanogaster Set8 and L(3)mbt function in gene expression independently of histone H4 lysine 20 methylation.
PR-Set7 fine-tunes the transcriptional activation of Wingless signaling in Drosophila
Title: The histone H4K20 methyltransferase PR-Set7 fine-tunes the transcriptional activation of Wingless signaling in Drosophila.
PR/SET domain containing protein 7 methyltransferase (PR-Set7) is targeted for degradation by the ubiquitin-proteasome pathway from G1 to early S phase in Drosophila S2 cells.
Title: Cell-cycle regulation of non-enzymatic functions of the Drosophila methyltransferase PR-Set7.
coincident with the ATR-dependent cell cycle arrest, increased DNA damage is specifically limited to late replicating regions of the Drosophila genome, suggesting that PR-Set7-mediated monomethylation of H4K20 is critical for maintaining the genomic integrity of late replicating domains
Title: Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
crystal structure reveals the basis of the specificity of the enzyme for histone H4-K20
Title: Specificity and mechanism of the histone methyltransferase Pr-Set7.
Results support the hypothesis that methylation of H4 lysine 20 by PR/Set7 maintains silent chromatin, in part, by precluding neighboring acetylation on the H4 tail
Title: PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables histone H4K20 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone H4K20 methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone H4K20 methyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables histone H4K20 monomethyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome condensation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome condensation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA damage response, signal transduction by p53 class mediator	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in polytene chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in polytene chromosome	IDA Inferred from Direct Assay more info	PubMed