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LIG3 DNA ligase 3 [ Gallus gallus (chicken) ]

Gene ID: 417530, updated on 3-Dec-2024

Summary

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Symbol
LIG3provided by CGNC
Full Name
DNA ligase 3provided by CGNC
Primary source
CGNC:1632
See related
Ensembl:ENSGALG00010029631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See LIG3 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
22
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (4989787..5005069, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (4718210..4733486, complement)

Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC121107263 Neighboring gene uncharacterized LOC101747457 Neighboring gene uncharacterized LOC101747270

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. Paul K, et al. PLoS One, 2013. PMID 23555685, Free PMC Article
  2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. functional flexibility and interchangeability between LIG1 and LIG3
    Title: DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA ligase (ATP) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in base-excision repair, DNA ligation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via alternative nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lagging strand elongation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mitochondrial DNA repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA ligase III-XRCC1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA ligase 3
Names
ligase III, DNA, ATP-dependent
NP_001006215.3
XP_015151212.2
XP_040506000.1
XP_040506001.1
XP_046786000.1
XP_046786001.1
XP_046786002.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006215.3 → NP_001006215.3  DNA ligase 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000323
    UniProtKB/TrEMBL
    A0A8V1ALB9
    Related
    ENSGALP00010044335.1, ENSGALT00010071645.1
    Conserved Domains (3) summary
    PLN03123
    Location:115 → 222
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    TIGR00574
    Location:335 → 847
    dnl1; DNA ligase I, ATP-dependent (dnl1)
    cd18431
    Location:933 → 1006
    BRCT_DNA_ligase_III; BRCT domain of DNA ligase 3 (LIG3) and similar proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    4989787..5005069 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040650066.2 → XP_040506000.1  DNA ligase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ALB9
    Conserved Domains (2) summary
    PLN03123
    Location:115 → 222
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    TIGR00574
    Location:335 → 844
    dnl1; DNA ligase I, ATP-dependent (dnl1)

  2. XM_040650067.2 → XP_040506001.1  DNA ligase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V1ALB9
    Conserved Domains (2) summary
    PLN03123
    Location:115 → 222
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    TIGR00574
    Location:335 → 844
    dnl1; DNA ligase I, ATP-dependent (dnl1)

  3. XM_015295726.4 → XP_015151212.2  DNA ligase 3 isoform X3

    Conserved Domains (2) summary
    PLN03123
    Location:115 → 222
    PLN03123; poly [ADP-ribose] polymerase; Provisional
    TIGR00574
    Location:335 → 800
    dnl1; DNA ligase I, ATP-dependent (dnl1)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    4718210..4733486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046930044.1 → XP_046786000.1  DNA ligase 3 isoform X1

    UniProtKB/TrEMBL
    A0A8V1ALB9

  2. XM_046930045.1 → XP_046786001.1  DNA ligase 3 isoform X2

    UniProtKB/TrEMBL
    A0A8V1ALB9

  3. XM_046930046.1 → XP_046786002.1  DNA ligase 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version

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