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HtrA2 HTRA2-related serine protease [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41756, updated on 4-Jan-2025

Summary

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Official Symbol
HtrA2provided by FlyBase
Official Full Name
HTRA2-related serine proteaseprovided by FlyBase
Primary source
FLYBASE:FBgn0038233
Locus tag
Dmel_CG8464
See related
AllianceGenome:FB:FBgn0038233
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8464; Dmel\CG8464; Dmel_CG8464; DmHtrA2; domi; dOmi; htrA2; HTRA2; htrA2/omi; HtrA2/Omi; omi; Omi; Omi/HtrA2
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including ectopic germ cell programmed cell death; mitochondrion organization; and spermatogenesis. Located in Nebenkern; cytosol; and mitochondrial intermembrane space. Is expressed in adult head and organism. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including 3-methylglutaconic aciduria type 8; CADASIL (multiple); gastrointestinal system cancer (multiple); macular degeneration (multiple); and neurodegenerative disease (multiple). Orthologous to several human genes including HTRA2 (HtrA serine peptidase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See HtrA2 in Genome Data Viewer
Location:
88C3-88C3; 3-55 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14509049..14511712, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10334771..10337434, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene crossveinless c Neighboring gene antisense RNA:CR44176 Neighboring gene natalisin Neighboring gene long non-coding RNA:CR44177 Neighboring gene mitochondrial ribosomal protein L11 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphodiesterase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuroprotective function of Omi to α-synuclein-induced neurotoxicity. Chung HJ, et al. Neurobiol Dis, 2020 Mar. PMID 31837423
  2. The HtrA2 Drosophila model of Parkinson's disease is suppressed by the pro-survival Bcl-2 Buffy. M'Angale PG, et al. Genome, 2017 Jan. PMID 27848260
  3. A conserved function for pericentromeric satellite DNA. Jagannathan M, et al. Elife, 2018 Mar 26. PMID 29578410, Free PMC Article
  4. Evolution of mitochondrial cell death pathway: Proapoptotic role of HtrA2/Omi in Drosophila. Igaki T, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17397804
  5. Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin. Whitworth AJ, et al. Dis Model Mech, 2008 Sep-Oct. PMID 19048081, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neuroprotective function of Omi to alpha-synuclein-induced neurotoxicity.
    Title: Neuroprotective function of Omi to α-synuclein-induced neurotoxicity.
  2. Mitochondrial serine protease HtrA2/Omi is an important mediator of germ cell death.
    Title: Alternative germ cell death pathway in Drosophila involves HtrA2/Omi, lysosomes, and a caspase-9 counterpart.
  3. Data show the presence of apoptosis at the cellular level in both ade2 and Prat mutants, and the upregulated gene HtrA2, which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.
    Title: A link between impaired purine nucleotide synthesis and apoptosis in Drosophila melanogaster.
  4. HtrA2 was shown to be phosphorylated in a PINK1-dependent manner, suggesting it might act in the PINK1 pathway.
    Title: Drosophila HtrA2 is dispensable for apoptosis but acts downstream of PINK1 independently from Parkin.
  5. found that Rhomboid-7, a mitochondrial protease not previously implicated in PD, acts as an upstream component of this pathway, and showed that it is required to cleave the precursor forms of both Pink1 and Omi
    Title: Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin.
  6. The binding of DIAP1 to dOmi resulted in DIAP1-mediated polyubiquitination of dOmi, suggesting that DIAP1 could target dOmi for proteasomal degradation.
    Title: The interaction of DIAP1 with dOmi/HtrA2 regulates cell death in Drosophila.
  7. Drosophila Omi (dOmi), a fly homologue of the serine protease Omi/HtrA2, alleviates th/DIAP1 inhibition of all caspases by proteolytically degrading th/DIAP1 and induces apoptosis both in cultured cells and in the developing fly eye.
    Title: Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ectopic germ cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in programmed cell death IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Nebenkern IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
HTRA2-related serine protease
Names
CG8464-PA
CG8464-PB
HtrA2-PA
HtrA2-PB
high temperature requirement A2
serine protease HTRA2
NP_001262565.1
NP_650366.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14509049..14511712 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275636.1 → NP_001262565.1  HTRA2-related serine protease, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262565.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VFJ3
    UniProtKB/TrEMBL
    A0A0B4KG52
    Conserved Domains (3) summary
    COG0265
    Location:67 → 422
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:323 → 417
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:141 → 280
    Trypsin_2; Trypsin-like peptidase domain

  2. NM_142109.2 → NP_650366.1  HTRA2-related serine protease, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650366.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VFJ3
    UniProtKB/TrEMBL
    A0A0B4KG52
    Related
    FBpp0082446
    Conserved Domains (3) summary
    COG0265
    Location:67 → 422
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    cd00987
    Location:323 → 417
    PDZ_serine_protease; PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind ...
    pfam13365
    Location:141 → 280
    Trypsin_2; Trypsin-like peptidase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG52 A0A0B4KG52
Q9VFJ3.1 Q9VFJ3

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