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jvl javelin-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41788, updated on 4-Jan-2025

Summary

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Official Symbol
jvlprovided by FlyBase
Official Full Name
javelin-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0263929
Locus tag
Dmel_CG43162
See related
AllianceGenome:FB:FBgn0263929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0153538.4; anon-WO0153538.5; CG33330; CG3563; CG43162; Dmel\CG43162; Jvl
Old locus tag
CG3563; Dmel_CG33330; Dmel_CG3563
Summary
Involved in several processes, including dorsal appendage formation; intracellular mRNA localization involved in anterior/posterior axis specification; and oogenesis. Located in microtubule cytoskeleton. Is expressed in egg chamber; larval apodeme; macrochaeta; nurse cell; and oocyte. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See jvl in Genome Data Viewer
Location:
88D2-88D3; 3-56 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14741582..14795868)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10567304..10621590)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene effete Neighboring gene Senescence marker protein-30 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like. Amsalem S, et al. Mol Cell Biol, 2013 Nov. PMID 24019068, Free PMC Article
  2. Actin filament turnover regulated by cross-linking accounts for the size, shape, location, and number of actin bundles in Drosophila bristles. Tilney LG, et al. Mol Biol Cell, 2003 Oct. PMID 14517310, Free PMC Article
  3. The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity. Baskar R, et al. FEBS J, 2019 Oct. PMID 31152621
  4. A transport and retention mechanism for the sustained distal localization of Spn-F-IKKε during Drosophila bristle elongation. Otani T, et al. Development, 2015 Jul 1. PMID 26092846, Free PMC Article
  5. Drosophila javelin-like encodes a novel microtubule-associated protein and is required for mRNA localization during oogenesis. Dubin-Bar D, et al. Development, 2011 Nov. PMID 21989913

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results show that the microtubule plus-end tracking and stabilizing activities of Jvl are central for controlling cell polarity of oocytes and bristles
    Title: The plus-tip tracking and microtubule stabilizing activities of Javelin-like regulate microtubule organization and cell polarity.
  2. Spn-F mediates the interaction between Ik2 and Jvl to control Ik2 activity.
    Title: Drosophila oocyte polarity and cytoskeleton organization require regulation of Ik2 activity by Spn-F and Javelin-like.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in actin filament bundle assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in anterior mRNA localization involved in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule-based transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte nucleus migration involved in oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in posterior mRNA localization involved in anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
javelin-like
Names
CG43162-PA
CG43162-PB
CG43162-PC
CG43162-PD
CG43162-PE
CG43162-PF
CG43162-PG
Javelin-Like
javelinlike
jvl-PA
jvl-PB
jvl-PC
jvl-PD
jvl-PE
jvl-PF
jvl-PG

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14741582..14795868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142132.4 → NP_650389.2  javelin-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650389.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQF1, Q9VFG3
    Related
    FBpp0296970
    Conserved Domains (1) summary
    cl23720
    Location:428 → 555
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  2. NM_001260176.2 → NP_001247105.1  javelin-like, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247105.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K682
    Conserved Domains (1) summary
    cl23720
    Location:428 → 555
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  3. NM_001260178.2 → NP_001247107.1  javelin-like, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6H8, D0IQF1
    Conserved Domains (1) summary
    cl23720
    Location:428 → 555
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  4. NM_001260177.2 → NP_001247106.1  javelin-like, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247106.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQF1, Q6NNB4
    Conserved Domains (1) summary
    cl23720
    Location:233 → 360
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  5. NM_001260179.2 → NP_001247108.1  javelin-like, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6X6, D0IQF1
    Conserved Domains (2) summary
    COG1340
    Location:250 → 359
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    pfam05109
    Location:536 → 947
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

  6. NM_001104323.3 → NP_001097793.1  javelin-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097793.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQF1, Q6NNB4
    Conserved Domains (1) summary
    cl23720
    Location:233 → 360
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

  7. NM_206488.2 → NP_996210.1  javelin-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996210.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D0IQF1, Q7KSJ6
    Conserved Domains (1) summary
    cl23720
    Location:234 → 361
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K682 A0A0B4K682
A0A0B4K6H8 A0A0B4K6H8
A0A0B4K6X6 A0A0B4K6X6
Q6NNB4 Q6NNB4
Q7KSJ6 Q7KSJ6
Q960P5 Q960P5
Q9VFG3 Q9VFG3

Gene LinkOut

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