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Sdr Secreted decoy of InR [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41809, updated on 4-Jan-2025

Summary

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Official Symbol
Sdrprovided by FlyBase
Official Full Name
Secreted decoy of InRprovided by FlyBase
Primary source
FLYBASE:FBgn0038279
Locus tag
Dmel_CG3837
See related
AllianceGenome:FB:FBgn0038279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3837; Dmel\CG3837; SDR
Summary
Enables insulin-like growth factor binding activity. Involved in several processes, including imaginal disc fusion, thorax closure; negative regulation of insulin receptor signaling pathway; and response to starvation. Located in extracellular space. Is expressed in several structures, including embryonic/larval hemolymph; embryonic/larval midgut; imaginal disc; larval central nervous system; and larval visceral muscle cell. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Sdr in Genome Data Viewer
Location:
88D7-88D7; 3-56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (14918628..14923083)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10744350..10748805)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase PPA1 subunit 1 Neighboring gene long non-coding RNA:CR46199 Neighboring gene long non-coding RNA:CR45598 Neighboring gene long non-coding RNA:CR45599

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Secreted decoy of insulin receptor is required for blood-brain and blood-retina barrier integrity in Drosophila. Kim J, et al. BMB Rep, 2023 Apr. PMID 36593109, Free PMC Article
  2. A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila. Yamada T, et al. Nat Metab, 2020 Oct. PMID 33046910
  3. Glycolytically impaired Drosophila glial cells fuel neural metabolism via β-oxidation. McMullen E, et al. Nat Commun, 2023 May 24. PMID 37225684, Free PMC Article
  4. Body size regulation and insulin-like growth factor signaling. Hyun S. Cell Mol Life Sci, 2013 Jul. PMID 23508807, Free PMC Article
  5. A secreted decoy of InR antagonizes insulin/IGF signaling to restrict body growth in Drosophila. Okamoto N, et al. Genes Dev, 2013 Jan 1. PMID 23307869, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables ATP binding IKR
Inferred from Key Residues
more info
 PubMed 
enables insulin-like growth factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables transmembrane receptor protein tyrosine kinase activity IKR
Inferred from Key Residues
more info
 PubMed 
Process Evidence Code Pubs
involved_in imaginal disc fusion, thorax closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
NOT located_in membrane IKR
Inferred from Key Residues
more info
 PubMed 

General protein information

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Preferred Names
secreted decoy of InR
Names
CG3837-PA
CG3837-PB
Sdr-PA
Sdr-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    14918628..14923083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300402.1 → NP_001287331.1  secreted decoy of InR, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287331.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNJ6, Q9VFE2
    Conserved Domains (3) summary
    smart00060
    Location:491 → 578
    FN3; Fibronectin type 3 domain
    pfam00757
    Location:209 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:347 → 461
    Recep_L_domain; Receptor L domain

  2. NM_142151.2 → NP_650408.1  secreted decoy of InR, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650408.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7FNJ6, Q9VFE2
    Related
    FBpp0082463
    Conserved Domains (3) summary
    smart00060
    Location:491 → 578
    FN3; Fibronectin type 3 domain
    pfam00757
    Location:209 → 332
    Furin-like; Furin-like cysteine rich region
    pfam01030
    Location:347 → 461
    Recep_L_domain; Receptor L domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T001 Q8T001
Q9VFE2 Q9VFE2

Gene LinkOut

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