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CG6966 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41816, updated on 4-Jan-2025

Summary

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Official Symbol
CG6966provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0038286
Locus tag
Dmel_CG6966
See related
AllianceGenome:FB:FBgn0038286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:AT05246; dFEM1A; Dmel\CG6966
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of ubiquitin-protein transferase activity. Predicted to be part of ubiquitin ligase complex. Orthologous to human FEM1A (fem-1 homolog A) and FEM1C (fem-1 homolog C). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG6966 in Genome Data Viewer
Location:
88E1-88E1; 3-56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15079320..15095631, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10905042..10921353, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 9 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2493 stem loop Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila. Avilés-Pagán EE, et al. G3 (Bethesda), 2020 Sep 2. PMID 32690584, Free PMC Article
  2. FEM1 proteins are ancient regulators of SLBP degradation. Dankert JF, et al. Cell Cycle, 2017 Mar 19. PMID 28118078, Free PMC Article
  3. Evaluation of the genomic extent of effects of fixed inversion differences on intraspecific variation and interspecific gene flow in Drosophila pseudoobscura and D. persimilis. Machado CA, et al. Genetics, 2007 Mar. PMID 17179068, Free PMC Article
  4. An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila. Li-Kroeger D, et al. Elife, 2018 Aug 9. PMID 30091705, Free PMC Article
  5. Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. Herranz R, et al. BMC Genomics, 2012 Feb 1. PMID 22296880, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG6966-PB
CG6966-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15079320..15095631 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300404.1 → NP_001287333.1  uncharacterized protein Dmel_CG6966, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287333.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IG97, Q8T4I2, Q9VFD5
    UniProtKB/TrEMBL
    A0A0B4LI92
    Conserved Domains (4) summary
    cd00204
    Location:110 → 234
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:87 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:182 → 234
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118 → 146
    ANK; ANK repeat [structural motif]

  2. NM_001104326.2 → NP_001097796.1  uncharacterized protein Dmel_CG6966, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097796.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8IG97, Q8T4I2, Q9VFD5
    UniProtKB/TrEMBL
    A0A0B4LI92
    Conserved Domains (4) summary
    cd00204
    Location:110 → 234
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:87 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:182 → 234
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118 → 146
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LI92 A0A0B4LI92
Q9VFD5.2 Q9VFD5

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