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Mf Myofilin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41824, updated on 9-Dec-2024

Summary

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Official Symbol
Mfprovided by FlyBase
Official Full Name
Myofilinprovided by FlyBase
Primary source
FLYBASE:FBgn0038294
Locus tag
Dmel_CG6803
See related
AllianceGenome:FB:FBgn0038294
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH23305; CG6803; Dmel\CG6803; DmMf; z1; Zeelin1
Summary
Located in A band. Is expressed in adult head; adult heart; larval muscle system; and larval somatic muscle cell. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
88E2-88E2; 3-56 cM
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15170625..15181510, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10996347..11007232, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene Glycogen synthase Neighboring gene Guanylyl cyclase at 88E Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1 Neighboring gene uncharacterized protein Neighboring gene Serpin 88Ea

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Myofilin, a protein in the thick filaments of insect muscle. Qiu F, et al. J Cell Sci, 2005 Apr 1. PMID 15769842
  2. Structure of the Drosophila melanogaster Flight Muscle Myosin Filament at 4.7 Å Resolution Reveals New Details of Non-Myosin Proteins. Abbasi Yeganeh F, et al. Int J Mol Sci, 2023 Oct 5. PMID 37834384, Free PMC Article
  3. Matrix metalloproteinase 1 modulates invasive behavior of tracheal branches during entry into Drosophila flight muscles. Sauerwald J, et al. Elife, 2019 Oct 2. PMID 31577228, Free PMC Article
  4. CryoEM structure of Drosophila flight muscle thick filaments at 7 Å resolution. Daneshparvar N, et al. Life Sci Alliance, 2020 Aug. PMID 32718994, Free PMC Article
  5. dLin52 is crucial for dE2F and dRBF mediated transcriptional regulation of pro-apoptotic gene hid. Bhaskar PK, et al. Biochim Biophys Acta, 2014 Sep. PMID 24863159

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
 PubMed 
located_in striated muscle myosin thick filament HDA PubMed 

General protein information

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Preferred Names
myofilin
Names
CG6803-PA
CG6803-PB
CG6803-PC
CG6803-PD
CG6803-PE
CG6803-PF
CG6803-PG
CG6803-PH
CG6803-PI
CG6803-PJ
CG6803-PK
CG6803-PL
CG6803-PM
CG6803-PN
CG6803-PO
CG6803-PP
CG6803-PQ
Mf-PA
Mf-PB
Mf-PC
Mf-PD
Mf-PE
Mf-PF
Mf-PG
Mf-PH
Mf-PI
Mf-PJ
Mf-PK
Mf-PL
Mf-PM
Mf-PN
Mf-PO
Mf-PP
Mf-PQ
zeelin
zeelin1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15170625..15181510 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170138.1 → NP_001163609.1  myofilin, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163609.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C553
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  2. NM_001275656.1 → NP_001262585.1  myofilin, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262585.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG65
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 131
    Myofilin

  3. NM_169612.1 → NP_731969.1  myofilin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731969.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INF1
    Related
    FBpp0082493, FBtr0083034
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  4. NM_001170140.1 → NP_001163611.1  myofilin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163611.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIK6
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  5. NM_169613.1 → NP_731970.1  myofilin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731970.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95U15
    Related
    FBpp0082492, FBtr0083033
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin

  6. NM_001170142.1 → NP_001163613.1  myofilin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C553
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  7. NM_001260185.1 → NP_001247114.1  myofilin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247114.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70VI1
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  8. NM_142166.2 → NP_650423.1  myofilin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650423.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SZ09, Q9VFC7
    Related
    FBpp0082490, FBtr0083031
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  9. NM_001260184.1 → NP_001247113.1  myofilin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247113.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q70VI1
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin; Myofilin

  10. NM_001170141.1 → NP_001163612.1  myofilin, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163612.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JIK9
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin

  11. NM_001300405.1 → NP_001287334.1  myofilin, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287334.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C529
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 97
    Myofilin; Myofilin

  12. NM_001300406.1 → NP_001287335.1  myofilin, isoform Q [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287335.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I062
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin

  13. NM_001275655.1 → NP_001262584.1  myofilin, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262584.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFC6
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 126
    Myofilin; Myofilin

  14. NM_001170139.1 → NP_001163610.1  myofilin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163610.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFC6
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 126
    Myofilin; Myofilin

  15. NM_169614.2 → NP_731971.1  myofilin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731971.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFC6
    Related
    FBpp0082489
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 126
    Myofilin; Myofilin

  16. NM_169615.2 → NP_731972.1  myofilin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731972.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I062
    Related
    FBpp0082491
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 133
    Myofilin

  17. NM_001260183.1 → NP_001247112.1  myofilin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C529
    Conserved Domains (1) summary
    pfam15929
    Location:1 → 97
    Myofilin; Myofilin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG65 A0A0B4KG65
C1C529 C1C529
C1C553 C1C553
E1JIK6 E1JIK6
E1JIK9 E1JIK9
Q70VI1 Q70VI1
Q70VI4 Q70VI4
Q8I062 Q8I062
Q8INF1 Q8INF1
Q95U15 Q95U15
Q9VFC6 Q9VFC6
Q9VFC7 Q9VFC7

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