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Art3 Arginine methyltransferase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41837, updated on 9-Dec-2024

Summary

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Official Symbol
Art3provided by FlyBase
Official Full Name
Arginine methyltransferase 3provided by FlyBase
Primary source
FLYBASE:FBgn0038306
Locus tag
Dmel_CG6563
See related
AllianceGenome:FB:FBgn0038306
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6563; DART3; Dmel\CG6563; PRMT3
Summary
Predicted to enable histone methyltransferase activity and protein-arginine omega-N monomethyltransferase activity. Predicted to be involved in chromatin remodeling and regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including anal pad primordium; anterior endoderm; embryonic anal pad; embryonic/larval midgut primordium; and gut section. Orthologous to human PRMT3 (protein arginine methyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See Art3 in Genome Data Viewer
Location:
88E3-88E3; 3-56 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15227605..15229408, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11053327..11055130, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Chromatin assembly factor 1, p55 subunit Neighboring gene mitochondrial ribosomal protein S10 Neighboring gene antisense RNA:CR43471 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
  2. Evolutionarily conserved protein arginine methyltransferases in non-mammalian animal systems. Wang YC, et al. FEBS J, 2012 Mar. PMID 22251447
  3. Identification of genes involved in the same pathways using a Hidden Markov Model-based approach. Senf A, et al. Bioinformatics, 2009 Nov 15. PMID 19720676
  4. Upregulation of ribosome biogenesis via canonical E-boxes is required for Myc-driven proliferation. Zielke N, et al. Dev Cell, 2022 Apr 25. PMID 35472319
  5. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Boulanger MC, et al. Biochem J, 2004 Apr 15. PMID 14705965, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N monomethyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-arginine methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
arginine methyltransferase 3
Names
Art3-PA
Art3-PB
CG6563-PA
CG6563-PB
NP_650434.1
NP_731984.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15227605..15229408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142177.4 → NP_650434.1  arginine methyltransferase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650434.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFB3
    Related
    FBpp0082588
    Conserved Domains (1) summary
    pfam12847
    Location:243 → 346
    Methyltransf_18; Methyltransferase domain

  2. NM_169623.4 → NP_731984.1  arginine methyltransferase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731984.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INE8
    Related
    FBpp0082589
    Conserved Domains (1) summary
    pfam12847
    Location:201 → 304
    Methyltransf_18; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8INE8 Q8INE8
Q9VFB3 Q9VFB3

Gene LinkOut

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