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ea easter [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41858, updated on 9-Dec-2024

Summary

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Official Symbol
eaprovided by FlyBase
Official Full Name
easterprovided by FlyBase
Primary source
FLYBASE:FBgn0000533
Locus tag
Dmel_CG4920
See related
AllianceGenome:FB:FBgn0000533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
c-SP24; CG4920; cSP24; Dmel\CG4920; Ea; EA; SP24
Summary
Enables serine-type endopeptidase activity. Involved in several processes, including Toll receptor ligand protein activation cascade; dorsal/ventral axis specification; and ventral furrow formation. Located in extracellular space and perivitelline space. Is expressed in organism and ovary. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
88F1-88F1; 3-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15328729..15330408)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11154451..11156130)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ENL/AF9-related Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L9 Neighboring gene FK506-binding protein 39kD Neighboring gene Cytoplasmic FMR1 interacting protein Neighboring gene N-acetylglucosamine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo. Chasan R, et al. Cell, 1989 Feb 10. PMID 2492450
  2. Dominant and recessive alleles of the Drosophila easter gene are point mutations at conserved sites in the serine protease catalytic domain. Jin YS, et al. Cell, 1990 Mar 9. PMID 2107028
  3. A common domain within the proenzyme regions of the Drosophila snake and easter proteins and Tachypleus proclotting enzyme defines a new subfamily of serine proteases. Smith CL, et al. Protein Sci, 1992 Sep. PMID 1304399, Free PMC Article
  4. In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain. Ursel C, et al. Biol Chem, 2013 Aug. PMID 23729565
  5. Mutational analysis of the Drosophila snake protease: an essential role for domains within the proenzyme polypeptide chain. Smith C, et al. Genetics, 1994 Apr. PMID 8013912, Free PMC Article

See all (172) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study reports the expression and refolding of Easter, and show that the renatured enzyme performs the activation cleavage of two spatzle isoforms.
    Title: In vitro maturation of Drosophila melanogaster Spätzle protein with refolded Easter reveals a novel cleavage site within the prodomain.
  2. observation suggests a mechanism in which the sulfated target of Pipe promotes a productive interaction between Snake and Easter, perhaps by facilitating conformational changes in a complex containing the two proteins
    Title: Pipe-dependent ventral processing of Easter by Snake is the defining step in Drosophila embryo DV axis formation.
  3. Easter plays a role in generating the wild-type shape of the Dorsal gradient in the developing Drosophila embryo
    Title: Regulation of Easter activity is required for shaping the Dorsal gradient in the Drosophila embryo.
  4. provision of three-dimensional model and role of cation binding sites in embryo patterning
    Title: Three-dimensional models of proteases involved in patterning of the Drosophila Embryo. Crucial role of predicted cation binding sites.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables serine-type endopeptidase activity ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in Toll receptor ligand protein activation cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in Toll receptor ligand protein activation cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in Toll receptor ligand protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in maternal specification of dorsal/ventral axis, oocyte, germ-line encoded TAS
Traceable Author Statement
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis ISM
Inferred from Sequence Model
more info
 PubMed 
involved_in ventral furrow formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perivitelline space IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
easter
Names
CG4920-PA
CG4920-PB
ea-PA
ea-PB
NP_001262597.1
NP_524362.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15328729..15330408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275668.1 → NP_001262597.1  easter, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262597.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGQ4
    Conserved Domains (2) summary
    smart00020
    Location:3 → 255
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:3 → 258
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_079638.3 → NP_524362.2  easter, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524362.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P13582, Q9VF90
    Related
    FBpp0082539
    Conserved Domains (3) summary
    smart00020
    Location:127 → 386
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:128 → 389
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam12032
    Location:37 → 89
    CLIP; Regulatory CLIP domain of proteinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGQ4 A0A0B4KGQ4
P13582.3 P13582

Gene LinkOut

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