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TLR7 toll like receptor 7 [ Gallus gallus (chicken) ]

Gene ID: 418638, updated on 3-Dec-2024

Summary

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Symbol
TLR7provided by CGNC
Full Name
toll like receptor 7provided by CGNC
Primary source
CGNC:12429
See related
Ensembl:ENSGALG00010001897
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See TLR7 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (123561394..123568153, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (123522887..123529646, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109491 Neighboring gene thymosin beta 4X Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene maestro heat-like repeat-containing protein family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of toll-like receptor-7 agonists on feeding behaviour, voluntary activity, cloacal temperature and crop emptying in chicks. Tachibana T, et al. Br Poult Sci, 2020 Jun. PMID 31973574
  2. Long-term (1 year) acceptability of perindopril in type II diabetic patients with hypertension. Jandrain B, et al. Am J Med, 1992 Apr 27. PMID 1580288
  3. Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway. Zhu J, et al. Arch Virol, 2020 Sep. PMID 32524263, Free PMC Article
  4. Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production. Abdul-Cader MS, et al. BMC Res Notes, 2018 Dec 4. PMID 30514372, Free PMC Article
  5. Downregulation of TLR4 and 7 mRNA expression levels in broiler's spleen caused by diets supplemented with nickel chloride. Huang J, et al. Biol Trace Elem Res, 2014 Jun. PMID 24643469

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.
    Title: Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.
  2. results showed that activation of TLR7 is associated with anorexia, hypoactivity, hypothermia, disturbance of feed passage in the digestive tract and the response to stress in chicks
    Title: Effects of toll-like receptor-7 agonists on feeding behaviour, voluntary activity, cloacal temperature and crop emptying in chicks.
  3. Antiviral response elicited against avian influenza virus infection following activation of TLR7 signaling pathway is attributable to interleukin IL-1beta production.
    Title: Antiviral response elicited against avian influenza virus infection following activation of toll-like receptor (TLR)7 signaling pathway is attributable to interleukin (IL)-1β production.
  4. Results show that the Toll-like receptors TLR4 and TLR7 that the mRNA expression levels in the spleen were lower in the 300, 600, and 900 mg/kg groups than those in the control group.
    Title: Downregulation of TLR4 and 7 mRNA expression levels in broiler's spleen caused by diets supplemented with nickel chloride.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pattern recognition receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor 7 signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
toll-like receptor 7
Names
toll-like receptor 7-long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011688.3 → NP_001011688.2  toll-like receptor 7

    Status: VALIDATED

    Source sequence(s)
    AJ720504, AJ740367, JAENSK010000024, KM486600, KM486601
    UniProtKB/TrEMBL
    A0A0A7M9V8, A0A0A7MEX8, A0A1L4FMI1, A0A1L4FMK6, A0A1L4FML6
    Related
    ENSGALP00010002615.1, ENSGALT00010004337.1
    Conserved Domains (6) summary
    PRK15370
    Location:40 → 196
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:763 → 849
    PCC; polycystin cation channel protein
    smart00255
    Location:900 → 1044
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:131 → 721
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:137 → 156
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:709 → 769
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    123561394..123568153 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015273651.4 → XP_015129137.2  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97
    Conserved Domains (5) summary
    PRK15370
    Location:32 → 188
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:755 → 841
    PCC; polycystin cation channel protein
    smart00255
    Location:892 → 1036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:123 → 713
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]

  2. XM_015273642.4 → XP_015129128.2  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97
    Conserved Domains (5) summary
    PRK15370
    Location:32 → 188
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:755 → 841
    PCC; polycystin cation channel protein
    smart00255
    Location:892 → 1036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:123 → 713
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]

  3. XM_015273647.4 → XP_015129133.2  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97
    Related
    ENSGALP00010002613.1, ENSGALT00010004335.1
    Conserved Domains (5) summary
    PRK15370
    Location:32 → 188
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    TIGR00864
    Location:755 → 841
    PCC; polycystin cation channel protein
    smart00255
    Location:892 → 1036
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:123 → 713
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    123522887..123529646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046908011.1 → XP_046763967.1  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97

  2. XM_046908009.1 → XP_046763965.1  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97

  3. XM_046908010.1 → XP_046763966.1  toll-like receptor 7 isoform X1

    UniProtKB/TrEMBL
    A0A8V0XDV1, Q5GQ97
Nucleotide Protein Strain
Heading Accession and Version

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