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FHL2 four and a half LIM domains 2 [ Gallus gallus (chicken) ]

Gene ID: 418726, updated on 3-Dec-2024

Summary

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Symbol
FHL2provided by CGNC
Full Name
four and a half LIM domains 2provided by CGNC
Primary source
CGNC:12600
See related
Ensembl:ENSGALG00010013232
Gene type
protein coding
RefSeq status
MODEL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See FHL2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (135254499..135293849, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (135211112..135250434, complement)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121108989 Neighboring gene transforming growth factor beta receptor associated protein 1 Neighboring gene C2orf49 homolog Neighboring gene uncharacterized LOC112531516 Neighboring gene uncharacterized LOC101751432 Neighboring gene uncharacterized LOC107051986

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Four and a half domain 2 (FHL2) scaffolding protein is a marker of connective tissues of developing digits and regulates fibrogenic differentiation of limb mesodermal progenitors. Lorda-Diez CI, et al. J Tissue Eng Regen Med, 2018 Apr. PMID 29330921
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fhl2 is involved in the differentiation of connective tissues of developing limb autopod.
    Title: Four and a half domain 2 (FHL2) scaffolding protein is a marker of connective tissues of developing digits and regulates fibrogenic differentiation of limb mesodermal progenitors.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription factor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of calcineurin-NFAT signaling cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
four and a half LIM domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    135254499..135293849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004938513.5 → XP_004938570.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3
    Related
    ENSGALP00010018607.1, ENSGALT00010031787.1
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_004938512.5 → XP_004938569.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3
    Related
    ENSGALP00010018609.1, ENSGALT00010031790.1
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_046899120.1 → XP_046755076.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3

  4. XM_040657381.2 → XP_040513315.1  four and a half LIM domains protein 2 isoform X2

    Conserved Domains (3) summary
    cd09431
    Location:54 → 110
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:113 → 170
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:1 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    135211112..135250434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040662187.2 → XP_040518121.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  2. XM_040662188.2 → XP_040518122.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3
    Conserved Domains (5) summary
    cd09422
    Location:36 → 97
    LIM1_FHL2; The first LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09426
    Location:101 → 157
    LIM2_FHL2; The second LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09431
    Location:162 → 218
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:221 → 278
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:5 → 33
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. XM_046909117.1 → XP_046765073.1  four and a half LIM domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YCT4, F1P4R3

  4. XM_040662190.2 → XP_040518124.1  four and a half LIM domains protein 2 isoform X2

    Conserved Domains (3) summary
    cd09431
    Location:54 → 110
    LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cd09433
    Location:113 → 170
    LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)
    cl02475
    Location:1 → 49
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
Nucleotide Protein Strain
Heading Accession and Version

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