Rh6 Rhodopsin 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rh6provided by FlyBase
Official Full Name: Rhodopsin 6provided by FlyBase
Primary source: FLYBASE:FBgn0019940
Locus tag: Dmel_CG5192
See related: AllianceGenome:FB:FBgn0019940
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5192; Dm Rh6; DMELRH6; Dmel\CG5192; r8; R8; Rh; rh6; RH6
Summary: Enables G protein-coupled photoreceptor activity. Involved in several processes, including entrainment of circadian clock by photoperiod; phototransduction; and thermotaxis. Is active in rhabdomere. Is expressed in several structures, including Bolwig nerve; larval multidendritic class IV neuron; photoreceptor neurons; rhabdomere of eye photoreceptor cell; and sense organ. Used to study sensorineural hearing loss. Orthologous to human OPN4 (opsin 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 88F6-88F6; 3-57 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (15483158..15484699)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (11308880..11310421)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study results show that both Ort and HisCl1 define two different pathways for circadian entrainment. Whereas Ort contributes through its expression in the interneurons of the optic lobe, HisCl1 mostly contributes through its expression in the Rh6-expressing retinal photoreceptors. The work thus reveals that Rh6-expressing neurons contribute to light-mediated entrainment as both photoreceptors and interneurons.
Title: The HisCl1 histamine receptor acts in photoreceptors to synchronize Drosophila behavioral rhythms with light-dark cycles.
Rh5 and Rh6 were required in trpA1-expressing neurons in the brain, ventral nerve cord, and body wall. Because Rh1 contributes to thermal selection in the comfortable range during the early to mid-third-instar stage, fine thermal discrimination depends on multiple rhodopsins.
Title: A Switch in Thermal Preference in Drosophila Larvae Depends on Multiple Rhodopsins.
Light reception mediated by Rh5 and Rh6 must utilize either a different (nonretinal) phospholipase C-beta enzyme or alternative signaling mechanisms, at least in terms of clock-relevant photoreception
Title: Rhodopsin 5- and Rhodopsin 6-mediated clock synchronization in Drosophila melanogaster is independent of retinal phospholipase C-β signaling.
during metamorphosis, all Rh6 photoreceptors die, whereas the Rh5 photoreceptors switch fate by turning off Rh5 and then turning on Rh6 expression
Title: Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables G protein-coupled photoreceptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled photoreceptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables G protein-coupled photoreceptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables G protein-coupled photoreceptor activity	NAS Non-traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cellular response to light stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in entrainment of circadian clock by photoperiod	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phototransduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phototransduction	IEA Inferred from Electronic Annotation more info
involved_in phototransduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phototransduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phototransduction	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in visual perception	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rhodopsin 6

Names: CG5192-PD; R8 rhodopsin; Rh6-PD; Rhodopsin6; rhodopsin; rhodopsin-6

NP_524368.5

insertional mutation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

15483158..15484699

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079644.3 → NP_524368.5 rhodopsin 6 [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

O01668, Q8SXF4, Q9VF58

Conserved Domains (1) summary

cd15079
Location:48 → 338

7tmA_photoreceptors_insect; insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors