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AOX2 Aldehyde oxidase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41895, updated on 9-Dec-2024

Summary

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Official Symbol
AOX2provided by FlyBase
Official Full Name
Aldehyde oxidase 2provided by FlyBase
Primary source
FLYBASE:FBgn0038348
Locus tag
Dmel_CG18519
See related
AllianceGenome:FB:FBgn0038348
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG18519; DmAO2; Dmel\CG18519
Summary
Enables aldehyde oxidase activity. Involved in cellular aldehyde metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See AOX2 in Genome Data Viewer
Location:
88F7-88F7; 3-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15537713..15542414, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11363435..11368136, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Aldehyde oxidase 1 Neighboring gene Aldehyde oxidase 3 Neighboring gene Aldehyde oxidase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The four aldehyde oxidases of Drosophila melanogaster have different gene expression patterns and enzyme substrate specificities. Marelja Z, et al. J Exp Biol, 2014 Jun 15. PMID 24737760, Free PMC Article
  2. Purification of the aldehyde oxidase homolog 1 (AOH1) protein and cloning of the AOH1 and aldehyde oxidase homolog 2 (AOH2) genes. Identification of a novel molybdo-flavoprotein gene cluster on mouse chromosome 1. Terao M, et al. J Biol Chem, 2001 Dec 7. PMID 11562361
  3. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
  4. Iron Sulfur and Molybdenum Cofactor Enzymes Regulate the Drosophila Life Cycle by Controlling Cell Metabolism. Marelja Z, et al. Front Physiol, 2018. PMID 29491838, Free PMC Article
  5. mRNA-Associated Processes and Their Influence on Exon-Intron Structure in Drosophila melanogaster. Lepennetier G, et al. G3 (Bethesda), 2016 Jun 1. PMID 27172210, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables aldehyde oxidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
aldehyde oxidase 2
Names
AOX2-PC
CG18519-PC
NP_732047.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15537713..15542414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169665.3 → NP_732047.2  aldehyde oxidase 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732047.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IND5
    Conserved Domains (7) summary
    smart01008
    Location:548 → 655
    Ald_Xan_dh_C; Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain
    PLN02906
    Location:24 → 1251
    PLN02906; xanthine dehydrogenase
    cd00207
    Location:3 → 84
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    pfam01799
    Location:86 → 159
    Fer2_2; [2Fe-2S] binding domain
    pfam02738
    Location:702 → 1184
    Ald_Xan_dh_C2; Molybdopterin-binding domain of aldehyde dehydrogenase
    pfam03450
    Location:391 → 497
    CO_deh_flav_C; CO dehydrogenase flavoprotein C-terminal domain
    cl19922
    Location:206 → 366
    FAD_binding_4; FAD binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IND5 Q8IND5

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