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Acyp2 Acylphosphatase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41910, updated on 4-Jan-2025

Summary

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Official Symbol
Acyp2provided by FlyBase
Official Full Name
Acylphosphatase 2provided by FlyBase
Primary source
FLYBASE:FBgn0038363
Locus tag
Dmel_CG18505
See related
AllianceGenome:FB:FBgn0038363
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AcPDro2; CG18505; Dmel\CG18505
Summary
Enables acylphosphatase activity. Predicted to be located in cytoplasm. Is expressed in adult head. Orthologous to human ACYP1 (acylphosphatase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Acyp2 in Genome Data Viewer
Location:
89A5-89A5; 3-58 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15792688..15793487)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11618410..11619209)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Uroporphyrinogen III synthase 2 Neighboring gene crossover suppressor on 3 of Gowen Neighboring gene non-specific lethal 1 Neighboring gene antisense RNA:CR45891 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amyloid formation of a protein in the absence of initial unfolding and destabilization of the native state. Soldi G, et al. Biophys J, 2005 Dec. PMID 16169977, Free PMC Article
  2. Stabilization of a native protein mediated by ligand binding inhibits amyloid formation independently of the aggregation pathway. Soldi G, et al. J Med Chem, 2006 Oct 5. PMID 17004719
  3. Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility. De Simone A, et al. Proc Natl Acad Sci U S A, 2011 Dec 27. PMID 22160682, Free PMC Article
  4. Drosophila melanogaster acylphosphatase: a common ancestor for acylphosphatase isoenzymes of vertebrate species. Pieri A, et al. FEBS Lett, 1998 Aug 21. PMID 9744795
  5. Characterization of a novel Drosophila melanogaster acylphosphatase. Degl'Innocenti D, et al. FEBS Lett, 2003 Jan 30. PMID 12560098

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acylphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acylphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acylphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
acylphosphatase 2
Names
Acyp2-PA
Acyp2-PB
CG18505-PA
CG18505-PB
acylphosphatase
NP_001262612.1
NP_650491.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15792688..15793487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275683.1 → NP_001262612.1  acylphosphatase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262612.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q29QI6, Q9VF36
    UniProtKB/TrEMBL
    A0A0B4KG16
    Conserved Domains (1) summary
    pfam00708
    Location:13 → 100
    Acylphosphatase

  2. NM_142234.2 → NP_650491.1  acylphosphatase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650491.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q29QI6, Q9VF36
    UniProtKB/TrEMBL
    A0A0B4KG16
    Related
    FBpp0082628
    Conserved Domains (1) summary
    pfam00708
    Location:13 → 100
    Acylphosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG16 A0A0B4KG16
Q9VF36.1 Q9VF36

Gene LinkOut

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