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nsl1 non-specific lethal 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41911, updated on 4-Jan-2025

Summary

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Official Symbol
nsl1provided by FlyBase
Official Full Name
non-specific lethal 1provided by FlyBase
Primary source
FLYBASE:FBgn0262527
Locus tag
Dmel_CG4699
See related
AllianceGenome:FB:FBgn0262527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4699; Dmel\CG4699; E(nos); l(3)06536; l(3)S009413; Nsl1; NSL1; wah
Summary
Enables chromatin binding activity and histone acetyltransferase binding activity. Involved in several processes, including germ-line stem cell population maintenance; germarium-derived female germ-line cyst formation; and larval somatic muscle development. Located in cytoplasm; nucleus; and polytene chromosome interband. Part of NSL complex. Is expressed in several structures, including adult central complex; brain; fat body; follicle cell; and germline cell. Used to study Koolen de Vries syndrome and intellectual disability. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to several human genes including KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See nsl1 in Genome Data Viewer
Location:
89A5-89A5; 3-58 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15793782..15802102)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11619504..11627824)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Uroporphyrinogen III synthase 2 Neighboring gene crossover suppressor on 3 of Gowen Neighboring gene Acylphosphatase 2 Neighboring gene antisense RNA:CR45891 Neighboring gene alpha-Mannosidase class II b Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutations in the chromatin modifier gene KANSL1 cause the 17q21.31 microdeletion syndrome. Koolen DA, et al. Nat Genet, 2012 Apr 29. PMID 22544363
  2. Tumor suppressor roles of CENP-E and Nsl1 in Drosophila epithelial tissues. Clemente-Ruiz M, et al. Cell Cycle, 2014. PMID 24626182, Free PMC Article
  3. Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation. Gaub A, et al. Nat Commun, 2020 May 7. PMID 32382029, Free PMC Article
  4. Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila. Lessing D, et al. PLoS Biol, 2008 Feb. PMID 18271626, Free PMC Article
  5. c(3)G encodes a Drosophila synaptonemal complex protein. Page SL, et al. Genes Dev, 2001 Dec 1. PMID 11731477, Free PMC Article

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in germ-line stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germarium-derived female germ-line cyst formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in larval somatic muscle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of NSL complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NSL complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of histone acetyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in polytene chromosome interband IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
non-specific lethal 1
Names
CG4699-PD
CG4699-PE
CG4699-PF
CG4699-PH
CG4699-PI
CG4699-PJ
CG4699-PK
CG4699-PL
CG4699-PM
CG4699-PN
CG4699-PO
CG4699-PP
lethal (3) 06536
nonspecific lethal 1
nsl1-PD
nsl1-PE
nsl1-PF
nsl1-PH
nsl1-PI
nsl1-PJ
nsl1-PK
nsl1-PL
nsl1-PM
nsl1-PN
nsl1-PO
nsl1-PP
waharan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15793782..15802102
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275684.1 → NP_001262613.1  non-specific lethal 1, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262613.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH7, E1JIM0
    Conserved Domains (1) summary
    pfam15275
    Location:1229 → 1304
    PEHE; PEHE domain

  2. NM_001170151.3 → NP_001163622.1  non-specific lethal 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163622.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH7, E1JIM0
    Conserved Domains (1) summary
    pfam15275
    Location:1229 → 1304
    PEHE; PEHE domain

  3. NM_001170152.2 → NP_001163623.1  non-specific lethal 1, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2Z1, B5RJH7
    Conserved Domains (1) summary
    pfam15275
    Location:1230 → 1305
    PEHE; PEHE domain

  4. NM_001260197.2 → NP_001247126.1  non-specific lethal 1, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K690, B5RJH7
    Conserved Domains (1) summary
    pfam15275
    Location:1231 → 1306
    PEHE; PEHE domain

  5. NM_142235.4 → NP_650492.2  non-specific lethal 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650492.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH7, Q0KI68
    Conserved Domains (1) summary
    pfam15275
    Location:1228 → 1303
    PEHE; PEHE domain

  6. NM_001170153.3 → NP_001163624.1  non-specific lethal 1, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163624.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7VEK2, E1JIM1
    Conserved Domains (1) summary
    PRK08581
    Location:100 → 323
    PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

  7. NM_001260195.2 → NP_001247124.1  non-specific lethal 1, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247124.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6Z4, B7VEK2
    Conserved Domains (1) summary
    PRK08581
    Location:100 → 323
    PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

  8. NM_169673.3 → NP_732070.2  non-specific lethal 1, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732070.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2Z1, B5RJH7
    Conserved Domains (1) summary
    pfam15275
    Location:1230 → 1305
    PEHE; PEHE domain

  9. NM_169672.4 → NP_732069.3  non-specific lethal 1, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732069.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5RJH7, E2QD16
    Conserved Domains (1) summary
    pfam15275
    Location:1250 → 1325
    PEHE; PEHE domain

  10. NM_001260194.2 → NP_001247123.1  non-specific lethal 1, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247123.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6I8, B7VEK2
    Conserved Domains (1) summary
    PRK08581
    Location:100 → 323
    PRK08581; N-acetylmuramoyl-L-alanine amidase; Validated

  11. NM_001260196.2 → NP_001247125.1  non-specific lethal 1, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247125.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K663, B5RJH7
    Conserved Domains (1) summary
    pfam15275
    Location:1249 → 1324
    PEHE; PEHE domain

  12. NM_001170150.3 → NP_001163621.1  non-specific lethal 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163621.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A4V2Z1, B5RJH7
    Conserved Domains (1) summary
    pfam15275
    Location:1230 → 1305
    PEHE; PEHE domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K663 A0A0B4K663
A0A0B4K690 A0A0B4K690
A0A0B4K6I8 A0A0B4K6I8
A0A0B4K6Z4 A0A0B4K6Z4
A4V2Z1 A4V2Z1
E1JIM0 E1JIM0
E1JIM1 E1JIM1
E2QD16 E2QD16
Q0KI68 Q0KI68

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