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glob1 globin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41930, updated on 9-Dec-2024

Summary

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Official Symbol
glob1provided by FlyBase
Official Full Name
globin 1provided by FlyBase
Primary source
FLYBASE:FBgn0027657
Locus tag
Dmel_CG9734
See related
AllianceGenome:FB:FBgn0027657
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9734; DmeGb1; dmeglob1; DmeGlob1; Dmel\CG9734; DmHb; DmHb1; DroHb; Glob1; globin1; Hb
Summary
Enables iron ion binding activity and oxygen binding activity. Predicted to be involved in oxygen transport and response to hypoxia. Located in plasma membrane. Is expressed in several structures, including epithelium; fat body; gonad; gut section; and imaginal disc. Human ortholog(s) of this gene implicated in several diseases, including acute chest syndrome; congenital hemolytic anemia (multiple); polycythemia (multiple); sickle cell disease (multiple); and thalassemia (multiple). Orthologous to several human genes including CYGB (cytoglobin). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See glob1 in Genome Data Viewer
Location:
89A8-89A8; 3-58 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15896926..15904643, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11722648..11730243, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene Endoribonuclease U-specific

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin. Ioanitescu AI, et al. Metallomics, 2009. PMID 21305121
  2. Knockdown of Drosophila hemoglobin suggests a role in O2 homeostasis. Gleixner E, et al. Insect Biochem Mol Biol, 2016 May. PMID 27001071
  3. Analysis of Mitochondrial haemoglobin in Parkinson's disease brain. Shephard F, et al. Mitochondrion, 2016 Jul. PMID 27181046, Free PMC Article
  4. Drosophila glob1 is required for the maintenance of cytoskeletal integrity during oogenesis. Yadav R, et al. Dev Dyn, 2016 Nov. PMID 27503269
  5. Neuroglobin and other hexacoordinated hemoglobins show a weak temperature dependence of oxygen binding. Uzan J, et al. Biophys J, 2004 Aug. PMID 15298922, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
    Title: Downregulation of glob1 mitigates human tau mediated neurotoxicity by restricting heterochromatin loss and elevating the autophagic response in drosophila.
  2. Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
    Title: Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation.
  3. Glob1 expression is essential for neurogenesis in Drosophila. Downregulation of glob1 causes mispositioning of neuronal precursor cells and neuromuscular disabilities.
    Title: Adequate expression of Globin1 is required for development and maintenance of nervous system in Drosophila.
  4. Authors have performed a comprehensive investigation on the cellular expression profile and functional relevance of glob1 in Drosophila development.
    Title: Drosophila glob1 expresses dynamically and is required for development and oxidative stress response.
  5. Several pH-dependent low-spin ferric haem forms are identified in a frozen solution of the ferric (1)(2)(1)Cys-->Ser mutant of Drosophila melanogaster haemoglobin (DmHb1*) using electron paramagnetic resonance (EPR) techniques.
    Title: Unusual flexibility of distal and proximal histidine residues in the haem pocket of Drosophila melanogaster haemoglobin.
  6. expression levels of dmeglob1 are decreased under both short- and long-term hypoxia
    Title: Oxygen-induced changes in hemoglobin expression in Drosophila.
  7. Characterization of Drosophila hemoglobin
    Title: Characterization of Drosophila hemoglobin. Evidence for hemoglobin-mediated respiration in insects.
  8. crystal structure of recombinant D. melanogaster hemoglobin at 1.20 A resolution displays a hexacoordinated heme, whose axial ligands are the proximal and distal His residues and three protein matrix cavities
    Title: Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.
  9. molecular characterization of human and Drosophila cytoglobulins and neuroglobulins
    Title: Hyperthermal stability of neuroglobin and cytoglobin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables heme binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables iron ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen binding IEA
Inferred from Electronic Annotation
more info
  
enables oxygen binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables oxygen carrier activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in oxygen transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oxygen transport IC
Inferred by Curator
more info
 PubMed 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
globin 1
Names
CG9734-PA
CG9734-PB
CG9734-PC
CG9734-PD
CG9734-PE
CG9734-PF
glob1-PA
glob1-PB
glob1-PC
glob1-PD
glob1-PE
glob1-PF
globin
haemoglobin
hemoglobin
hemoglobin gene 1
NP_001163625.1
NP_001287343.1
NP_524369.1
NP_732081.1
NP_732082.1
NP_732083.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15896926..15904643 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300414.2 → NP_001287343.1  globin 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287343.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K3, Q9VF15
    Conserved Domains (1) summary
    cd01040
    Location:9 → 142
    Mb_like; myoglobin_like; M family globin domain

  2. NM_169679.3 → NP_732082.1  globin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732082.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K3, Q9VF15
    Related
    FBpp0082699
    Conserved Domains (1) summary
    cd01040
    Location:9 → 142
    Mb_like; myoglobin_like; M family globin domain

  3. NM_169680.3 → NP_732083.1  globin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732083.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K3, Q9VF15
    Related
    FBpp0082702
    Conserved Domains (1) summary
    cd01040
    Location:9 → 142
    Mb_like; myoglobin_like; M family globin domain

  4. NM_079645.4 → NP_524369.1  globin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K3, Q9VF15
    Related
    FBpp0082700
    Conserved Domains (1) summary
    cd01040
    Location:9 → 142
    Mb_like; myoglobin_like; M family globin domain

  5. NM_169678.2 → NP_732081.1  globin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U1K3, Q9VF15
    Related
    FBpp0082701
    Conserved Domains (1) summary
    cd01040
    Location:9 → 142
    Mb_like; myoglobin_like; M family globin domain

  6. NM_001170154.3 → NP_001163625.1  globin 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163625.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T0T2
    Conserved Domains (1) summary
    cl21461
    Location:9 → 59
    Globin-like; Globin-like protein superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8T0T2 Q8T0T2
Q9U1K3 Q9U1K3
Q9VF15 Q9VF15

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