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EndoU Endoribonuclease U-specific [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41931, updated on 9-Dec-2024

Summary

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Official Symbol
EndoUprovided by FlyBase
Official Full Name
Endoribonuclease U-specificprovided by FlyBase
Primary source
FLYBASE:FBgn0038381
Locus tag
Dmel_CG3303
See related
AllianceGenome:FB:FBgn0038381
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3303; dendoU; Dmel\CG3303
Summary
Enables RNA endonuclease activity. Involved in adult locomotory behavior; negative regulation of lipid catabolic process; and post-transcriptional regulation of gene expression. Is expressed in adult head; embryonic/larval posterior spiracle; and organism. Orthologous to human ENDOU (endonuclease, poly(U) specific). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See EndoU in Genome Data Viewer
Location:
89A8-89A8; 3-58 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15908398..15910367)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11734120..11736089)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene globin 1 Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46470 Neighboring gene F-box and leucine-rich repeat protein 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration. Laneve P, et al. Sci Rep, 2017 Jan 31. PMID 28139767, Free PMC Article
  2. The endoribonuclease Arlr is required to maintain lipid homeostasis by downregulating lipolytic genes during aging. Sun X, et al. Nat Commun, 2023 Oct 6. PMID 37803019, Free PMC Article
  3. Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response. Hollien J, et al. Science, 2006 Jul 7. PMID 16825573
  4. GlycoFly: a database of Drosophila N-linked glycoproteins identified using SPEG--MS techniques. Baycin-Hizal D, et al. J Proteome Res, 2011 Jun 3. PMID 21480662
  5. Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. Okada H, et al. Nat Commun, 2016 Sep 1. PMID 27582081, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of lipid catabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in post-transcriptional gene silencing IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
endoribonuclease U-specific
Names
CG3303-PA
EndoU-PA
drosophila endoribonuclease U-specific

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15908398..15910367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142251.4 → NP_650508.1  endoribonuclease U-specific [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650508.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q960Q7, Q9VF14
    Related
    FBpp0082654
    Conserved Domains (1) summary
    pfam09412
    Location:55 → 319
    XendoU; Endoribonuclease XendoU
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VF14 Q9VF14

Gene LinkOut

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