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Rbf2 - Retinoblastoma-family protein 2

Enables transcription cis-regulatory region binding activity and transcription corepressor activity. Involved in negative regulation of G1/S transition of mitotic cell cycle and negative regulation of transcription by RNA polymerase II. Part of DRM complex; Myb complex; and Rb-E2F complex. Is expressed in several structures, including antennal anlage; antennal primordium; ganglia; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in several diseases, including high grade glioma (multiple); osteosarcoma; prostate cancer; retinoblastoma (multiple); and small cell carcinoma. Orthologous to human RB1 (RB transcriptional corepressor 1); RBL1 (RB transcriptional corepressor like 1); and RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Nov 2024]

Genes similar to Rbf2

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Species Gene Architecture aa