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Ttc1 Tetratricopeptide repeat domain 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41993, updated on 4-Jan-2025

Summary

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Official Symbol
Ttc1provided by FlyBase
Official Full Name
Tetratricopeptide repeat domain 1provided by FlyBase
Primary source
FLYBASE:FBgn0038428
Locus tag
Dmel_CG14894
See related
AllianceGenome:FB:FBgn0038428
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG14894; Dmel\CG14894; dTtc1
Summary
Located in cytosol. Is expressed in embryonic/larval midgut and organism. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Ttc1 in Genome Data Viewer
Location:
89B16-89B16; 3-58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16441843..16443007, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12267565..12268729, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein S33 Neighboring gene endosomal maturation defective Neighboring gene uncharacterized protein Neighboring gene Pak3 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dTtc1, a conserved tetratricopeptide repeat protein, is required for maturation of Drosophila egg chambers via its role in stabilizing electron transport chain components. Neiswender H, et al. Front Cell Dev Biol, 2023. PMID 37333987, Free PMC Article
  2. The structure and population genetics of the breakpoints associated with the cosmopolitan chromosomal inversion In(3R)Payne in Drosophila melanogaster. Matzkin LM, et al. Genetics, 2005 Jul. PMID 15781702, Free PMC Article
  3. Expression of Mst89B and CG31287 is Needed for Effective Sperm Storage and Egg Fertilization in Drosophila. Grewal G, et al. Cells, 2021 Feb 1. PMID 33535499, Free PMC Article
  4. Genetic variants regulating expression levels and isoform diversity during embryogenesis. Cannavò E, et al. Nature, 2017 Jan 19. PMID 28024300
  5. Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina. Thanawala SU, et al. Dev Cell, 2013 Apr 15. PMID 23597484, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tetratricopeptide repeat domain 1
Names
CG14894-PA
CG14894-PB
Ttc1-PA
Ttc1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16441843..16443007 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275707.1 → NP_001262636.1  tetratricopeptide repeat domain 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262636.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEV3
    Conserved Domains (4) summary
    smart00028
    Location:167 → 198
    TPR; Tetratricopeptide repeats
    sd00006
    Location:94 → 122
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:133 → 166
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:93 → 164
    TPR_11; TPR repeat

  2. NM_142286.3 → NP_650543.1  tetratricopeptide repeat domain 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650543.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEV3
    Related
    FBpp0082765
    Conserved Domains (4) summary
    smart00028
    Location:167 → 198
    TPR; Tetratricopeptide repeats
    sd00006
    Location:94 → 122
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:133 → 166
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:93 → 164
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VEV3 Q9VEV3

Gene LinkOut

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