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Fas1 Fasciclin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42025, updated on 9-Dec-2024

Summary

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Official Symbol
Fas1provided by FlyBase
Official Full Name
Fasciclin 1provided by FlyBase
Primary source
FLYBASE:FBgn0285925
Locus tag
Dmel_CG6588
See related
AllianceGenome:FB:FBgn0285925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6588; Dmel\CG6588; DROFAS; DROFAS1; DROFASI; fas I; Fas I; fas-I; fas1; fasI; FasI; FGM222E05; gasI; MRE24
Summary
Enables cell adhesion molecule binding activity. Involved in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and neuron development. Located in plasma membrane. Is expressed in several structures, including cuboidal/columnar epithelium; ganglia; larval CNS neuron; neuron projection bundle; and sense organ. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See Fas1 in Genome Data Viewer
Location:
89D5-89D6; 3-59 cM
Exon count:
18
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16625238..16639771)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12450960..12465493)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Coiled-coil domain containing protein 114 Neighboring gene nonA-like Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing of micro-exons creates multiple forms of the insect cell adhesion molecule fasciclin I. McAllister L, et al. J Neurosci, 1992 Mar. PMID 1545245, Free PMC Article
  2. Expression and structural studies of fasciclin I, an insect cell adhesion molecule. Wang WC, et al. J Biol Chem, 1993 Jan 15. PMID 8419345
  3. Altered nerve terminal arborization and synaptic transmission in Drosophila mutants of cell adhesion molecule fasciclin I. Zhong Y, et al. J Neurosci, 1995 Oct. PMID 7472428, Free PMC Article
  4. Derivation-dependent distribution of insertion sites for a Drosophila transposon. Ising G, et al. Cold Spring Harb Symp Quant Biol, 1981. PMID 6266746
  5. Drosophila fasciclin I, a neural cell adhesion molecule, has a phosphatidylinositol lipid membrane anchor that is developmentally regulated. Hortsch M, et al. J Biol Chem, 1990 Sep 5. PMID 2394715

See all (130) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cell adhesion molecule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron recognition IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
fasciclin 1
Names
CG6588-PA
CG6588-PB
CG6588-PC
CG6588-PD
CG6588-PE
CG6588-PF
CG6588-PG
Fas1-PA
Fas1-PB
Fas1-PC
Fas1-PD
Fas1-PE
Fas1-PF
Fas1-PG
Fasciclin-1
fasciclin I
mRNA-like ncRNA in embryogenesis 24

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16625238..16639771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275716.1 → NP_001262645.1  fasciclin 1, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262645.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KH94
    Conserved Domains (2) summary
    smart00554
    Location:355 → 463
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:31 → 146
    Fasciclin; Fasciclin domain

  2. NM_001144594.2 → NP_001138066.1  fasciclin 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138066.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0L0
    Conserved Domains (2) summary
    smart00554
    Location:355 → 463
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:31 → 146
    Fasciclin; Fasciclin domain

  3. NM_001104344.2 → NP_001097814.1  fasciclin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097814.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8JR25
    Conserved Domains (2) summary
    smart00554
    Location:368 → 476
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:488 → 627
    Fasciclin; Fasciclin domain

  4. NM_169724.2 → NP_732164.1  fasciclin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732164.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8INA9
    Related
    FBpp0082784
    Conserved Domains (2) summary
    smart00554
    Location:361 → 469
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:481 → 620
    Fasciclin; Fasciclin domain

  5. NM_001144593.2 → NP_001138065.1  fasciclin 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138065.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0L1
    Conserved Domains (2) summary
    smart00554
    Location:355 → 463
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:475 → 614
    Fasciclin; Fasciclin domain

  6. NM_169725.2 → NP_732165.1  fasciclin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732165.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P10674
    Related
    FBpp0082783
    Conserved Domains (2) summary
    smart00554
    Location:358 → 466
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:478 → 617
    Fasciclin; Fasciclin domain

  7. NM_169726.2 → NP_732166.1  fasciclin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_732166.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VES3
    Related
    FBpp0082782
    Conserved Domains (2) summary
    smart00554
    Location:355 → 463
    FAS1; Four repeated domains in the Fasciclin I family of proteins, present in many other contexts
    pfam02469
    Location:475 → 614
    Fasciclin; Fasciclin domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KH94 A0A0B4KH94
A8JR25 A8JR25
B7Z0L0 B7Z0L0
B7Z0L1 B7Z0L1
P10674.1 P10674
Q8INA9 Q8INA9
Q8MSW3 Q8MSW3
Q9VES3 Q9VES3

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