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Mettl4 Methyltransferase like 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42030, updated on 4-Jan-2025

Summary

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Official Symbol
Mettl4provided by FlyBase
Official Full Name
Methyltransferase like 4provided by FlyBase
Primary source
FLYBASE:FBgn0015351
Locus tag
Dmel_CG14906
See related
AllianceGenome:FB:FBgn0015351
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-89Eb; CG14906; Dmel\CG14906; mettl4; METTL4; ORF2
Summary
Enables U2 snRNA adenosine m6 methyltransferase activity. Involved in snRNA methylation. Is expressed in organism. Orthologous to human METTL4 (methyltransferase 4, N6-adenosine). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Mettl4 in Genome Data Viewer
Location:
89D6-89D6; 3-59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16649981..16651157, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12475703..12476879, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 Neighboring gene uncharacterized protein Neighboring gene Chaperonin containing TCP1 subunit 3 Neighboring gene uncharacterized protein Neighboring gene modular serine protease

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CG14906 (mettl4) mediates m(6)A methylation of U2 snRNA in Drosophila. Gu L, et al. Cell Discov, 2020. PMID 32637152, Free PMC Article
  2. N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease. Shafik AM, et al. Genome Biol, 2021 Jan 5. PMID 33402207, Free PMC Article
  3. Mathematical model to predict regions of chromatin attachment to the nuclear matrix. Singh GB, et al. Nucleic Acids Res, 1997 Apr 1. PMID 9060438, Free PMC Article
  4. Complete sequence of the bithorax complex of Drosophila. Martin CH, et al. Proc Natl Acad Sci U S A, 1995 Aug 29. PMID 7667301, Free PMC Article
  5. m(6)A modulates neuronal functions and sex determination in Drosophila. Lence T, et al. Nature, 2016 Dec 8. PMID 27919077

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables U2 snRNA adenosine m6 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in snRNA methylation IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
methyltransferase like 4
Names
CG14906-PC
Mettl4-PC
open reading frame 2
NP_650573.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    16649981..16651157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142316.2 → NP_650573.1  methyltransferase like 4 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650573.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VER8
    Related
    FBpp0307589
    Conserved Domains (1) summary
    pfam05063
    Location:155 → 335
    MT-A70; MT-A70
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24112 Q24112
Q9VER8 Q9VER8

Gene LinkOut

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