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SPAG6 sperm associated antigen 6 [ Gallus gallus (chicken) ]

Gene ID: 420505, updated on 3-Dec-2024

Summary

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Official Symbol
SPAG6provided by CGNC
Official Full Name
sperm associated antigen 6provided by CGNC
Primary source
CGNC:5970
See related
Ensembl:ENSGALG00010004222
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See SPAG6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (17601772..17640365, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (17629474..17668074, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol-5-phosphate 4-kinase type 2 alpha Neighboring gene uncharacterized LOC112531962 Neighboring gene microRNA mir-12240 Neighboring gene BMI1 proto-oncogene, polycomb ring finger Neighboring gene COMM domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of sperm-associated antigen 6 expression in the reproductive tract of the domestic rooster (Gallus domesticus) and its impact on sperm mobility. Jarrell ZR, et al. Poult Sci, 2020 Nov. PMID 33142536, Free PMC Article
  2. Gene expression of Spag6 in chick central nervous system. Hamada T, et al. Anat Histol Embryol, 2010 Jun. PMID 20394600
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterization of sperm-associated antigen 6 expression in the reproductive tract of the domestic rooster (Gallus domesticus) and its impact on sperm mobility.
    Title: Characterization of sperm-associated antigen 6 expression in the reproductive tract of the domestic rooster (Gallus domesticus) and its impact on sperm mobility.
  2. Results identify sperm-associated antigen 6 (Spag6) as a gene with a dynamic expression profile within the chick embryonic spinal cord.
    Title: Gene expression of Spag6 in chick central nervous system.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in epithelial cilium movement involved in extracellular fluid movement IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron projection extension IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sperm axoneme assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in axoneme IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sperm principal piece IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sperm-associated antigen 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199586.2 → NP_001186515.2  sperm-associated antigen 6

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000036
    UniProtKB/TrEMBL
    E1C6P7, M1T4J8
    Related
    ENSGALP00010005756.1, ENSGALT00010009873.1
    Conserved Domains (3) summary
    COG5064
    Location:81 → 415
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:289 → 325
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:120 → 152
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    17601772..17640365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040680802.2 → XP_040536736.1  sperm-associated antigen 6 isoform X2

    Conserved Domains (3) summary
    COG5064
    Location:174 → 459
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:383 → 406
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:215 → 247
    ARM; armadillo repeat [structural motif]

  2. XM_025147182.3 → XP_025002950.1  sperm-associated antigen 6 isoform X1

    Conserved Domains (3) summary
    sd00044
    Location:384 → 420
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:215 → 247
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:176 → 510
    Arm_3; Atypical Arm repeat

  3. XM_040680805.2 → XP_040536739.1  sperm-associated antigen 6 isoform X5

    UniProtKB/TrEMBL
    M1T4J8
    Conserved Domains (3) summary
    COG5064
    Location:11 → 358
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:288 → 311
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:120 → 152
    ARM; armadillo repeat [structural motif]

  4. XM_046921928.1 → XP_046777884.1  sperm-associated antigen 6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XLT9

  5. XM_046921925.1 → XP_046777881.1  sperm-associated antigen 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XJ10, A0A8V0XLT9

  6. XM_015281383.3 → XP_015136869.1  sperm-associated antigen 6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XLT9
    Related
    ENSGALP00010005754.1, ENSGALT00010009870.1
    Conserved Domains (3) summary
    COG5064
    Location:74 → 408
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:282 → 318
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:113 → 145
    ARM; armadillo repeat [structural motif]

  7. XM_040680803.2 → XP_040536737.1  sperm-associated antigen 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XJ10, A0A8V0XLT9
    Conserved Domains (3) summary
    COG5064
    Location:99 → 433
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00044
    Location:307 → 343
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:138 → 170
    ARM; armadillo repeat [structural motif]

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    17629474..17668074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911001.1 → XP_046766957.1  sperm-associated antigen 6 isoform X2

  2. XM_046911000.1 → XP_046766956.1  sperm-associated antigen 6 isoform X1

  3. XM_046911006.1 → XP_046766962.1  sperm-associated antigen 6 isoform X5

    UniProtKB/TrEMBL
    M1T4J8

  4. XM_046911005.1 → XP_046766961.1  sperm-associated antigen 6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XLT9

  5. XM_046911002.1 → XP_046766958.1  sperm-associated antigen 6 isoform X3

    UniProtKB/TrEMBL
    A0A8V0XLT9

  6. XM_046911003.1 → XP_046766959.1  sperm-associated antigen 6 isoform X6

    UniProtKB/TrEMBL
    A0A8V0XLT9

  7. XM_046911004.1 → XP_046766960.1  sperm-associated antigen 6 isoform X4

    UniProtKB/TrEMBL
    A0A8V0XLT9
Nucleotide Protein
Heading Accession and Version

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