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Dad - Daughters against dpp

Enables BMP receptor binding activity. Involved in several processes, including imaginal disc morphogenesis; intestinal stem cell homeostasis; and negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Located in cytosol and nucleus. Is expressed in several structures, including adult pacemaker neurons; follicle cell; germline cell; gut section; and larval imaginal tissue. Human ortholog(s) of this gene implicated in aortic valve disease 2; colorectal cancer; craniosynostosis 7; pancreatic adenocarcinoma; and radioulnar synostosis. Orthologous to human SMAD6 (SMAD family member 6) and SMAD7 (SMAD family member 7). [provided by Alliance of Genome Resources, Dec 2024]

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Species Gene Architecture aa