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GckIII Germinal centre kinase III [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42064, updated on 4-Jan-2025

Summary

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Official Symbol
GckIIIprovided by FlyBase
Official Full Name
Germinal centre kinase IIIprovided by FlyBase
Primary source
FLYBASE:FBgn0266465
Locus tag
Dmel_CG5169
See related
AllianceGenome:FB:FBgn0266465
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5169; dGckIII; dGCKIII; Dmel\CG5169; Gck III; GCKIII; STLK3; wheezy
Summary
Predicted to enable protein homodimerization activity and protein serine/threonine kinase activity. Involved in septate junction assembly and trachea morphogenesis. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Is expressed in adult head. Orthologous to several human genes including STK24 (serine/threonine kinase 24) and STK25 (serine/threonine kinase 25). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See GckIII in Genome Data Viewer
Location:
89E12-89E12; 3-59 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17085513..17087988)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12911235..12913710)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Keap1 Neighboring gene kugelkern Neighboring gene chromosome alignment defect 1 Neighboring gene cheerio Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The farnesylated nuclear proteins KUGELKERN and LAMIN B promote aging-like phenotypes in Drosophila flies. Brandt A, et al. Aging Cell, 2008 Aug. PMID 18494863
  2. A Hippo-like Signaling Pathway Controls Tracheal Morphogenesis in Drosophila melanogaster. Poon CLC, et al. Dev Cell, 2018 Dec 3. PMID 30458981, Free PMC Article
  3. Applications of high-throughput RNA interference screens to problems in cell and developmental biology. Perrimon N, et al. Genetics, 2007 Jan. PMID 17244760, Free PMC Article
  4. STRIPAK regulates Slik localization to control mitotic morphogenesis and epithelial integrity. De Jamblinne CV, et al. J Cell Biol, 2020 Nov 2. PMID 32960945, Free PMC Article
  5. The mammalian family of sterile 20p-like protein kinases. Delpire E. Pflugers Arch, 2009 Sep. PMID 19399514

See all (59) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCM3 and GCKIII prevent tube dilation in Drosophila trachea; tube dilation is suppressed by reduction of NSF2
    Title: Focal defects in single-celled tubes mutant for Cerebral cavernous malformation 3, GCKIII, or NSF2.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in septate junction assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in trachea morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
germinal centre kinase III
Names
CG5169-PA
GckIII-PA
germinal center kinase III
wheezy
NP_650596.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17085513..17087988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142339.3 → NP_650596.1  germinal centre kinase III [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IGS1, Q9VEN3
    Related
    FBpp0082840
    Conserved Domains (2) summary
    smart00220
    Location:13 → 263
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06609
    Location:12 → 283
    STKc_MST3_like; Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IGS1 Q8IGS1
Q9VEN3 Q9VEN3

Gene LinkOut

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