cal1 chromosome alignment defect 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cal1provided by FlyBase
Official Full Name: chromosome alignment defect 1provided by FlyBase
Primary source: FLYBASE:FBgn0038478
Locus tag: Dmel_CG5148
See related: AllianceGenome:FB:FBgn0038478
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Cal1; CAL1; CG5148; CLD2; Dmel\CG5148
Summary: Enables chromatin-protein adaptor activity. Involved in several processes, including CENP-A containing chromatin assembly; female meiosis chromosome segregation; and regulation of kinetochore assembly. Located in kinetochore and nucleolus. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 89E12-89E12; 3-59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (17088280..17091938)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (12914002..12917660)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Title: Structural basis for centromere maintenance by Drosophila CENP-A chaperone CAL1.
Mitosis length is influenced by the spindle assembly checkpoint (SAC), and authors found that CAL1 interacts with the SAC protein and RZZ complex component Zw10 and thus constitutes the anchor for the recruitment of RZZ.
Title: The checkpoint protein Zw10 connects CAL1-dependent CENP-A centromeric loading and mitosis duration in Drosophila cells.
centromere assembly factors CAL1 and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility
Title: Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis.
identify two co-evolving regions, CENP-A L1 and the CAL1 N terminus, as critical for lineage-specific CENP-A incorporation
Title: Co-evolving CENP-A and CAL1 Domains Mediate Centromeric CENP-A Deposition across Drosophila Species.
CENP-A assembly by its loading factor, CAL1, requires RNAPII-mediated transcription of the underlying DNA
Title: Establishment of Centromeric Chromatin by the CENP-A Assembly Factor CAL1 Requires FACT-Mediated Transcription.
Targeting CAL1 to noncentromeric DNA in Drosophila cells is sufficient to heritably recruit CENP-A, kinetochore proteins, and microtubule attachments.
Title: CAL1 is the Drosophila CENP-A assembly factor.
Centromere proteins CENP-C and CAL1 are required in Drosophila meiosis for centromere pairing and clustering at the nucleolus.
Title: Centromere proteins CENP-C and CAL1 functionally interact in meiosis for centromere clustering, pairing, and chromosome segregation.
The centromere proteins CAL1 and CENP-C are both required for CID assembly in meiosis and normal progression through spermatogenesis.
Title: The cell cycle timing of centromeric chromatin assembly in Drosophila meiosis is distinct from mitosis yet requires CAL1 and CENP-C.
The nucleolar function of modulo which is regulating the assembly of the centromere by directing the localization of CAL1.
Title: A role for the CAL1-partner Modulo in centromere integrity and accurate chromosome segregation in Drosophila.
prevents centromere expansion and mitotic kinetochore failure when Cenp-A/Cid and Cenp-C are present in excess
Title: Detrimental incorporation of excess Cenp-A/Cid and Cenp-C into Drosophila centromeres is prevented by limiting amounts of the bridging factor Cal1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin-protein adaptor activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in CENP-A containing chromatin assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in female meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to chromosome, centromeric region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of kinetochore assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric region	IDA Inferred from Direct Assay more info	PubMed
located_in kinetochore	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed