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m-cup mann-cup [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42076, updated on 4-Jan-2025

Summary

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Official Symbol
m-cupprovided by FlyBase
Official Full Name
mann-cupprovided by FlyBase
Primary source
FLYBASE:FBgn0038488
Locus tag
Dmel_CG11896
See related
AllianceGenome:FB:FBgn0038488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG11896; Dmel\CG11896
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Is expressed in elongation stage spermatid; organism; and primary spermatocyte. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See m-cup in Genome Data Viewer
Location:
89F1-89F1; 3-60 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17144475..17149412, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12970197..12975134, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene TweedleW Neighboring gene Deterin Neighboring gene Single-strand-selective monofunctional uracil-DNA glycosylase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. Cammarata-Mouchtouris A, et al. PLoS Pathog, 2020 Apr. PMID 32339205, Free PMC Article
  2. Post-meiotic transcription in Drosophila testes. Barreau C, et al. Development, 2008 Jun. PMID 18434411
  3. Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster. Dunn JG, et al. Elife, 2013 Dec 3. PMID 24302569, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mann-cup
Names
CG11896-PA
CG11896-PB
m-cup-PA
m-cup-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17144475..17149412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275731.1 → NP_001262660.1  mann-cup, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262660.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHA0, Q8T3S0
    Conserved Domains (4) summary
    cd00204
    Location:147 → 262
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:149 → 239
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:244 → 294
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:177 → 208
    ANK; ANK repeat [structural motif]

  2. NM_142350.2 → NP_650607.1  mann-cup, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650607.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8T3S0, Q9I7J2
    Related
    FBpp0082855
    Conserved Domains (4) summary
    cd00204
    Location:147 → 262
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:149 → 239
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:244 → 294
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:177 → 208
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHA0 A0A0B4KHA0
Q8T3S0 Q8T3S0
Q9I7J2 Q9I7J2

Gene LinkOut

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