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lute lute [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42089, updated on 9-Dec-2024

Summary

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Official Symbol
luteprovided by FlyBase
Official Full Name
luteprovided by FlyBase
Primary source
FLYBASE:FBgn0262871
Locus tag
Dmel_CG43226
See related
AllianceGenome:FB:FBgn0262871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.289; CG14333; CG43226; CG5319; Dmel\CG43226
Old locus tag
Dmel_CG14333; Dmel_CG5319
Summary
Involved in neurogenesis. Predicted to be active in cytosol. Is expressed in larval central nervous system; larval peripheral nervous system; and organism. Orthologous to several human genes including BTBD3 (BTB domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See lute in Genome Data Viewer
Location:
90A3-90A5; 3-60 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17379944..17390265)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13205666..13215987)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene beaten path IIa Neighboring gene long non-coding RNA:CR44256 Neighboring gene long non-coding RNA:CR43196 Neighboring gene Brf RNA polymerase III subunit Neighboring gene antisense RNA:CR44160 Neighboring gene sds22 Neighboring gene Cellular Repressor of E1A-stimulated Genes

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xenopus BTBD6 and its Drosophila homologue lute are required for neuronal development. Bury FJ, et al. Dev Dyn, 2008 Nov. PMID 18855900
  2. Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination. Gao Y, et al. Mol Cell, 2022 Apr 7. PMID 35325613
  3. Mating-responsive genes in reproductive tissues of female Drosophila melanogaster. Mack PD, et al. Proc Natl Acad Sci U S A, 2006 Jul 5. PMID 16798875, Free PMC Article
  4. Functional screening of mammalian mechanosensitive genes using Drosophila RNAi library- Smarcd3/Bap60 is a mechanosensitive pro-inflammatory gene. Kumar S, et al. Sci Rep, 2016 Nov 7. PMID 27819340, Free PMC Article
  5. Transcriptional regulators form diverse groups with context-dependent regulatory functions. Stampfel G, et al. Nature, 2015 Dec 3. PMID 26550828

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
lute
Names
CG43226-PA
CG43226-PB
CG43226-PC
CG43226-PD
lute-PA
lute-PB
lute-PC
lute-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17379944..17390265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001260221.1 → NP_001247150.1  lute, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247150.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAF3
    Conserved Domains (4) summary
    smart00225
    Location:263 → 365
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:371 → 477
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:254 → 361
    BTB; BTB/POZ domain
    pfam08005
    Location:522 → 665
    PHR; PHR domain

  2. NM_001260220.1 → NP_001247149.1  lute, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247149.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C7LAF3
    Conserved Domains (4) summary
    smart00225
    Location:263 → 365
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:371 → 477
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:254 → 361
    BTB; BTB/POZ domain
    pfam08005
    Location:522 → 665
    PHR; PHR domain

  3. NM_001275734.2 → NP_001262663.1  lute, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGU2
    Conserved Domains (4) summary
    smart00225
    Location:213 → 315
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:321 → 427
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:204 → 311
    BTB; BTB/POZ domain
    pfam08005
    Location:472 → 615
    PHR; PHR domain

  4. NM_142361.5 → NP_650618.1  lute, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650618.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VEL0
    Related
    FBpp0082876
    Conserved Domains (4) summary
    smart00225
    Location:213 → 315
    BTB; Broad-Complex, Tramtrack and Bric a brac
    smart00875
    Location:321 → 427
    BACK; BTB And C-terminal Kelch
    pfam00651
    Location:204 → 311
    BTB; BTB/POZ domain
    pfam08005
    Location:472 → 615
    PHR; PHR domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGU2 A0A0B4KGU2
C7LAF3 C7LAF3
Q86M55 Q86M55
Q9VEL0 Q9VEL0

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