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DROSHA drosha ribonuclease III [ Gallus gallus (chicken) ]

Gene ID: 420911, updated on 3-Dec-2024

Summary

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Symbol
DROSHAprovided by CGNC
Full Name
drosha ribonuclease IIIprovided by CGNC
Primary source
CGNC:9781
See related
Ensembl:ENSGALG00010011033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
RNASEN
Orthologs
human mouse all
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Genomic context

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See DROSHA in Genome Data Viewer
Location:
chromosome: 2
Exon count:
34
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (68901985..68974035)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (68886789..68958332)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121113081 Neighboring gene melanocortin 4 receptor Neighboring gene C5orf22 Neighboring gene cadherin 6 Neighboring gene uncharacterized LOC124417730

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables double-stranded RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in primary miRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease 3
Names
drosha, ribonuclease type III
ribonuclease III, nuclear
ribonuclease type III, nuclear
NP_001006379.2
NP_001383288.1
NP_001383289.1
NP_001383290.1
NP_001383291.1
NP_001383292.1
XP_046780377.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006379.3 → NP_001006379.2  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  2. NM_001396359.1 → NP_001383288.1  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  3. NM_001396360.1 → NP_001383289.1  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  4. NM_001396361.1 → NP_001383290.1  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Related
    ENSGALP00010015050.1, ENSGALT00010026441.1
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  5. NM_001396362.1 → NP_001383291.1  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

  6. NM_001396363.1 → NP_001383292.1  ribonuclease 3

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000040
    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3
    Conserved Domains (3) summary
    PRK00102
    Location:1067 → 1295
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:919 → 1033
    RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
    TIGR01642
    Location:208 → 312
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    68901985..68974035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046924421.1 → XP_046780377.1  ribonuclease 3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YGC5, Q5ZIR3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    68886789..68958332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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