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Eh Eclosion hormone [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42101, updated on 9-Dec-2024

Summary

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Official Symbol
Ehprovided by FlyBase
Official Full Name
Eclosion hormoneprovided by FlyBase
Primary source
FLYBASE:FBgn0000564
Locus tag
Dmel_CG5400
See related
AllianceGenome:FB:FBgn0000564
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5400; DMEHAB; Dmel\CG5400; Drm-EH; eh; EH; EHAB
Summary
Predicted to enable eclosion hormone activity. Involved in ecdysis, chitin-based cuticle. Predicted to be located in extracellular space. Is expressed in several structures, including adult central brain; embryonic central brain neurons; embryonic/larval anterior spiracle; embryonic/larval tracheal section; and neurosecretory cell of brain. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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Location:
90B1-90B1; 3-61 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (17446642..17448858, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13272364..13274580, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Curly Su Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Down syndrome cell adhesion molecule 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation, characterization and expression of the eclosion hormone gene of Drosophila melanogaster. Horodyski FM, et al. Eur J Biochem, 1993 Jul 15. PMID 8344291
  2. The hormonal coordination of behavior and physiology at adult ecdysis in Drosophila melanogaster. Baker JD, et al. J Exp Biol, 1999 Nov. PMID 10518485
  3. Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program. Baker JD, et al. J Exp Biol, 2002 Sep. PMID 12151362
  4. Neuroendocrine control of larval ecdysis behavior in Drosophila: complex regulation by partially redundant neuropeptides. Clark AC, et al. J Neurosci, 2004 Apr 28. PMID 15115824, Free PMC Article
  5. Anatomical characterization of PDF-tri neurons and peptidergic neurons associated with eclosion behavior in Drosophila. Selcho M, et al. J Comp Neurol, 2018 Jun 1. PMID 29427506

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ecdysis-triggering hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables eclosion hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables eclosion hormone activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables neuropeptide hormone activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in ecdysis, chitin-based cuticle IEA
Inferred from Electronic Annotation
more info
  
involved_in ecdysis, chitin-based cuticle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eclosion TAS
Traceable Author Statement
more info
 PubMed 
involved_in neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in neuropeptide signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of eclosion ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space ISM
Inferred from Sequence Model
more info
 PubMed 

General protein information

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Preferred Names
eclosion hormone
Names
CG5400-PA
CG5400-PB
Eh-PA
Eh-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    17446642..17448858 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275739.1 → NP_001262668.1  eclosion hormone, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07892, Q4V3X3, Q9VEJ8
    UniProtKB/TrEMBL
    A0A0B4KGU5
    Conserved Domains (1) summary
    pfam04736
    Location:36 → 96
    Eclosion; Eclosion hormone

  2. NM_079662.3 → NP_524386.1  eclosion hormone, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524386.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q07892, Q4V3X3, Q9VEJ8
    UniProtKB/TrEMBL
    A0A0B4KGU5
    Related
    FBpp0082885
    Conserved Domains (1) summary
    pfam04736
    Location:36 → 96
    Eclosion; Eclosion hormone
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGU5 A0A0B4KGU5
Q07892.1 Q07892

Gene LinkOut

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