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MC5R melanocortin 5 receptor [ Gallus gallus (chicken) ]

Gene ID: 421047, updated on 17-Aug-2024

Summary

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Symbol
MC5Rprovided by CGNC
Full Name
melanocortin 5 receptorprovided by CGNC
Primary source
CGNC:10393
See related
Ensembl:ENSGALG00010001415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See MC5R in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (96126496..96131037, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (96204366..96208909, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109739 Neighboring gene melanocortin 2 receptor Neighboring gene uncharacterized LOC124417683 Neighboring gene uncharacterized LOC121109926 Neighboring gene RNA guanine-7 methyltransferase Neighboring gene family with sequence similarity 210 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism. Zhang X, et al. Front Physiol, 2022. PMID 36277187, Free PMC Article
  2. Molecular and pharmacological characterization of poultry (Gallus gallus, Anas platyrhynchos, Anser cygnoides domesticus) and pig (Sus scrofa domestica) melanocortin-5 receptors and their mutants. Min T, et al. Gen Comp Endocrinol, 2019 Nov 1. PMID 31356812
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings demonstrated that presence of interspecies differences for MC5Rs, particularly for the pERK1/2 pathway.
    Title: Molecular and pharmacological characterization of poultry (Gallus gallus, Anas platyrhynchos, Anser cygnoides domesticus) and pig (Sus scrofa domestica) melanocortin-5 receptors and their mutants.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables melanocortin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
melanocortin receptor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031015.2 → NP_001026186.2  melanocortin receptor 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000042
    UniProtKB/TrEMBL
    A0A1D5P8Y9
    Related
    ENSGALP00010001713.1, ENSGALT00010003256.1
    Conserved Domains (1) summary
    cd15354
    Location:37 → 306
    7tmA_MC5R; melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001398329.1 → NP_001385258.1  melanocortin receptor 5 isoform a

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000042
    UniProtKB/TrEMBL
    A0A1D5P8Y9
    Conserved Domains (1) summary
    cd15354
    Location:37 → 306
    7tmA_MC5R; melanocortin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_001398330.1 → NP_001385259.1  melanocortin receptor 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000042

  4. NM_001398331.1 → NP_001385260.1  melanocortin receptor 5 isoform b

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000042

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    96126496..96131037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046925153.1 → XP_046781109.1  melanocortin receptor 5 isoform X1

    UniProtKB/TrEMBL
    A0A1D5P8Y9

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    96204366..96208909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911544.1 → XP_046767500.1  melanocortin receptor 5 isoform X1

    UniProtKB/TrEMBL
    O73671
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials